Abstract:Objective To investigate the efficacy and safety of oral vestibular approach endoscopic thyroid surgery in the treatment of benign thyroid tumors. Methods From July 2020 to May 2021, 120 cases diagnosed as benign thyroid tumors and indicated for endoscopic thyroid surgery in Guiping People’s Hospital, Guangxi Zhuang Autonomous Region were selected as the research objects. According to the random number table method, they were divided into observation group and control group, with 60 cases in each group. The observation group received oral vestibular approach laparoscopic thyroid surgery, and control group received transfrontal approach laparoscopic thyroid surgery. The operation time, surgical blood loss, total wound discharge, postoperative pain time, complication rate, patients’ incision satisfaction, postoperative neck movement comfort, and social adaptability were compared between two groups. Results The operation time and postoperative pain time in observation group were shorter than those in control group, the surgical blood loss and total wound discharge were less than those in control group, and the complication rate was lower than that in control group (P < 0.05). The incision satisfaction in observation group was higher than that in control group (P < 0.05). The incidence of postoperative pillow discomfort, maladjustment of auxiliary tools, pain and discomfort, high temperature, and other neck discomfort in observation group were lower than those in control group (P < 0.05). Before surgery, there was no significant difference in social adaptability scores between two groups (P > 0.05); after surgery, the social adaptability scores in both groups were higher than those before surgery, and observation group was higher than control group (P < 0.05). Conclusion Compared with transfrontal approach laparoscopic thyroid surgery, oral vestibular approach laparoscopic thyroid surgery for benign thyroid tumors can achieve better perioperative indicators, with higher postoperative neck activity comfort, higher incision satisfaction, and stronger postoperative social adaptability.