Abstract：Objective To investigate the influencing factors of hyperfractionated intensity-modulated radiotherapy for advanced non-small cell lung cancer (NSCLC). Methods A total of 127 patients with advanced NSCLC who received three months of hyperfractionated intensity-modulated radiotherapy in the 904th Hospital of People’s Liberation Army from January 2017 to February 2020 were selected as subjects. According to the response evaluation criteria in solid tumors (version 1.1), patients were divided into disease progression (PD) group (29 cases) and non-PD group (98 cases). The clinical data of the two groups and the levels of serum tumor abnormal protein (TAP), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) before radiotherapy were compared, and the factors influencing the efficacy of large fractionated intensity-modulated radiotherapy in patients with advanced NSCLC were analyzed. Results Age ＞ 65 years old, proportion of TNM stage Ⅳ, and serum TAP level before radiotherapy in PD group were higher than those in non-PD group, CEA and CA19-9 levels were lower than those in non-PD group, the differences were statistically significant (P < 0.05). The results of multivariate analysis showed that age, TNM stage, and serum TAP, CEA, CA19-9 levels before radiotherapy were all influencing factors for the efficacy of hyperfractionated intensity-modulated radiotherapy in advanced NSCLC patients (P ＜ 0.05). Conclusion Age, TNM stage, and serum TAP, CEA, CA19-9 levels before radiotherapy are related to the efficacy of hyperfractionated intensity-modulated radiotherapy in advanced NSCLC patients.
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