Clinical observation of the effect of Jianpi Yangxue Decoction combined with chemotherapy of gastric cancer#br#
LI Chengyin1 XU Yifang1 ZHAO Jingling2 GONG Hongwei1 JU Mengying3 YANG Jie3 ZHU Lu3
1.Department of Oncology, Hubei Provincial Hospital of Traditional Chinses Medicine, Hubei Province, Wuhan 430061, China;
2.Department of Obstetrics and Gynecology, Huangjiahu Hospital, Hubei University of Chinses Medicine, Hubei Province, Wuhan 430065, China;
3.Clinical College of Traditional Chinses Medicine, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China
Abstract：Objective To explore the efficacy and safety evaluation of Jianpi Yangxue Decoction combined with Capecitabine and Oxaliplatin (CAPOX) chemotherapy for patients with gastric cancer. Methods A total of 120 gastric cancer patients admitted to Hubei Provincial Hospital of Traditional Chinese Medicine from January 2018 to December 2020 were selected as the research subjects, and they were divided by lottery into observation group (Jianpi Yangxue Decoction + CAPOX chemotherapy regimen) and control group (CAPOX chemotherapy regimen), with 60 patients in each group. After two sessions, traditional Chinses medicine syndrome score, the Eastern Cooperative Oncology Group (ECOG) score, tumor markers (carcinoembryonic antigen [CEA] and carbohydrate antigen 19-9 [CA19-9]) levels, and the occurrence of adverse reaction of chemotherapy (Ⅱ-Ⅳ degrees of bone marrow supression [white blood cells, platelets, hemoglobin], liver and kidney function, gastrointestinal reaction, and peripheral nerve toxicity) were compared in two groups. Results There were six cases of detachment in the observation group and five cases in the control group, and 109 cases were included in the study. After treatment, traditional Chinses medicine syndrome score, CEA, and CA19-9 levels in both groups were lower than those before the treatment, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). ECOG score of observation group before and after treatment had no statistical significance (P ＞ 0.05). After treatment, the ECOG score of the control group was higher than that before the treatment, and observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). The incidences of hemoglobin Ⅱ-Ⅳ degrees of bone marrow supression, gastrointestinal reaction, and peripheral neurotoxicity in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion After the addition of Jianpi Yangxue Decoction to gastric cancer patients receiving chemotherapy, it can improve the traditional Chinses medicine symptoms, quality of life, and the expression of tumor markers, reduce the adverse reactions caused by chemotherapy, and play a synergistic and toxic role.
李成银1 徐忆芳1 赵井苓2 龚红卫1 鞠梦莹3 杨杰3 朱露3. 健脾养血方联合化疗治疗胃癌的临床效果[J]. 中国医药导报, 2022, 19(8): 89-92.
LI Chengyin1 XU Yifang1 ZHAO Jingling2 GONG Hongwei1 JU Mengying3 YANG Jie3 ZHU Lu3. Clinical observation of the effect of Jianpi Yangxue Decoction combined with chemotherapy of gastric cancer#br#. 中国医药导报, 2022, 19(8): 89-92.
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