Relationship between 25-OH-D level in cord blood and therapeutic effect of Ambroxol Hydrochloride in children with neonatal pneumonia#br#
GAN Yiwen1 CHENG Rui2▲ QI Rong3
1.Department of Neonatology, the Affiliated Jiangning Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 211100, China;
2.Neonatal Medical Center, Children’s Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 211100, China;
3.Department of Obstetrics, the Affiliated Jiangning Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 211100, China
Abstract：Objective To analyze the relationship between 25-hydroxyvitamin (OH)-D level in cord blood and therapeutic effect of Ambroxol Hydrochloride in children with neonatal pneumonia (NP). Methods A total of 100 cases of NP children treated in the Affiliated Jiangning Hospital of Nanjing Medical University from February to June 2021 were selected, all children were treated with Ambroxol Hydrochloride, at three days of treatment, the therapeutic effect of children was evaluated, and they were divided into effective group and ineffective group. 25-OH-D level in cord blood of children at birth and the serum indexes (procalcitonin [PCT], C-reactive protein [CRP]) before treatment were detected, the relationship between 25-OH-D level in cord blood and therapeutic effect of Ambroxol Hydrochloride in NP children were analyzed. Results The effective rate of Ambroxol Hydrochloride treatment was 86.00%. Serum PCT and CRP level in ineffective group were higher than those in effective group, and 25-OH-D level in cord blood was lower than those in effective group (P < 0.05). The expression levels of serum PCT, CRP, and 25-OH-D in cord blood were the influencing factors of the ineffective treatment of Ambroxol Hydrochloride in NP childre (P < 0.05). When the cut-off value was 80.655 nmol/L, cord blood 25-OH-D predicted that the AUC of Ambroxol Hydrochloride treatment in NP children was 0.810 (95%CI: 0.725-0.895). Conclusion Cord blood 25-OH-D level can predict the risk of failure to ambroxol treatment in NP children.
甘轶文1 程锐2▲ 祁蓉3. 脐血25-OH-D水平与新生儿肺炎患儿盐酸氨溴索治疗效果的关系[J]. 中国医药导报, 2022, 19(8): 85-88.
GAN Yiwen1 CHENG Rui2▲ QI Rong3. Relationship between 25-OH-D level in cord blood and therapeutic effect of Ambroxol Hydrochloride in children with neonatal pneumonia#br#. 中国医药导报, 2022, 19(8): 85-88.
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