Abstract：Objective To explore the clinical effect of Houpo Paiqi Mixture in the treatment of patients with sepsis acute gastrointestinal injury. Methods A total of 40 patients with sepsis acute gastrointestinal injury hospitalized in the Department of Critical Care Medicine of the First Affiliated Hospital of Anhui University of Chinese Medicine from April 2020 to May 2021 were selected as the research objects. They were divided into control group and intervention group according to random number table method, with 20 cases in each group, the control group was treated with conventional Western medicine, the intervention group was treated with Houpo Paiqi Mixture on the basis of the control group, 7 days for a course of treatment. The changes of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), the number of bowel sounds, enteral nutrition, sequential organ failure assessment score (SOFA), acute physiology and chronic health score Ⅱ (APACHE Ⅱ), and clinical effects were observed in the two groups. Results After treatment, hS-CRP and PCT in the two groups were lower than those before treatment, and the intervention group was lower than those in the control group (P ＜ 0.05). After treatment, the frequency of bowel sounds and enteral nutrition in the two groups were higher than those before treatment, and the intervention group was higher than those in the control group (P ＜ 0.05). After treatment, SOFA score and APACHE Ⅱ score of the two groups were lower than those before treatment, and the intervention group was lower than those in the control group (P ＜ 0.05). The clinical effect of intervention group was better than that in the control group (P ＜ 0.05). Conclusion Houpo Paiqi Mixture for patients with sepsis acute gastrointestinal injury is better than simple treatment of Western medicine, can reduce inflammatory reaction, improve gastrointestinal function, reduce the degree of critical illness, also improve the prognosis.
李魏 俞兴群 高志凌 聂卫群 王龙梅. 厚朴排气合剂治疗脓毒症急性胃肠损伤患者的临床研究[J]. 中国医药导报, 2022, 19(7): 141-144.
LI Wei YU Xingqun GAO Zhiling NIE Weiqun WANG Longmei. Clinical study of Houpo Paiqi Mixture in the treatment of patients with sepsis acute gastrointestinal injury#br#. 中国医药导报, 2022, 19(7): 141-144.
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