LncRNA在食管癌中的研究进展

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摘要食管癌是一种在全世界范围内常见的恶性肿瘤。由于食管癌缺乏特异性的肿瘤标志物，难以及时有效地监测肿瘤的发生发展、耐药的发生及有效的评估预后，致使临床治疗效果不佳。许多研究表明，长链非编码RNA（lncRNA）是功能基因组元件，可以在多个水平上发挥作用。近年来发现多种lncRNA在食管癌中异常表达，这些异常表达的lncRNA在食管癌发生发展的过程中发挥促癌或抑癌作用，并与食管癌的治疗耐药、预后等密切相关，lncRNA有望成为新的诊断或治疗的生物靶点。

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	汪萍1 胡欣1 刘康2 别俊1

关键词 ：食管癌, 长链非编码RNA, 生物标志物, 诊断, 治疗, 预后

Abstract：Esophageal cancer is a common malignant tumor all over the world. Due to the lack of specific tumor markers for esophageal cancer, it is difficult to timely and effectively monitor the occurrence and development of tumor, the occurrence of drug resistance and the effective evaluation of prognosis, resulting in poor clinical treatment effect. Many studies have shown that long non-coding RNA (lncRNA) is a functional genomic element, which can play roles at multiple levels. In recent years, a variety of lncRNA have been found to be abnormally expressed in esophageal cancer. These abnormally expressed lncRNA can promote or inhibit cancer in the occurrence and development of esophageal cancer, and are closely related to drug resistance and prognosis of esophageal cancer. lncRNA is expected to become new biological targets for diagnosis or treatment.

Key words： Esophageal cancer Long non-coding RNA Biomarkers Diagnosis Treatment Prognosis

基金资助:四川省科技计划项目（2019YJ0707、2018SZ0377）；
四川省南充市市校战略合作科技专项项目（18SXHZ0381、18SXHZ0370）。

通讯作者: 别俊（1976-），男，医学博士，南充市中心医院肿瘤科主任，四川省卫健委学术技术带头人，主要从事肿瘤规范化综合治疗及晚期癌症的姑息治疗工作。

作者简介: 汪萍（1995-），女，川北医学院2019级肿瘤学专业在读硕士研究生，主要从事食管癌综合治疗工作。

引用本文:

汪萍1 胡欣1 刘康2 别俊1. LncRNA在食管癌中的研究进展[J]. 中国医药导报, 2022, 19(7): 51-54.
WANG Ping1 HU Xin1 LIU Kang2 BIE Jun1. Research progress of LncRNA in esophageal cancer#br#. 中国医药导报, 2022, 19(7): 51-54.

链接本文:

https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I7/51

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