Abstract:Allergen molecular component diagnosis plays an important role in the diagnosis of allergic diseases. Airborne plant pollen is one of the main causes of seasonal allergic diseases, and the seasonal distribution characteristics vary in different regions, resulting in the regional specificity of different pollen sensitization to humans. This paper reviews the research status of component diagnosis of airborne pollen allergens in children at home and abroad, regional differences in sensitization, component detection technology differences, component cross reaction, and other aspects. It provides a reference for the diagnosis, immunotherapy, and further prevention of allergic diseases in children’s respiratory tract, and provides a new idea for the study of component diagnosis in airborne pollen sensitization.
宋惠芳1 王育民2. 儿童气传花粉变应原分子组分诊断研究进展[J]. 中国医药导报, 2022, 19(7): 43-46.
SONG Huifang1 WANG Yumin2. Research progress in diagnosis of molecular components of airborne pollen allergens in children. 中国医药导报, 2022, 19(7): 43-46.
[1] 毛杰,卢晴晴,曾辛,等.过敏原检测方法的研究进展[J].中华预防医学杂志,2021,55(1):123-129.
[2] 孙院芳.免疫印迹法与皮肤点刺法在过敏性皮肤疾病过敏原检测中的应用价值分析[J].基层医学论坛,2019,23(581):99-100.
[3] González-Mancebo E,Domínguez-Ortega J,Blanco-Bermejo S,et al. Comparison of two diagnostic techniques,skin-prick test and component resolved diagnosis in the follow-up of a cohort of paediatric patients with pollinosis. Multicentre pilot study in a highly exposed allergenic area [J]. Allergol Immunopathol (Madr),2017,45(2):121-126.
[4] Saltabayeva U,Garib V,Morenko M,et al. Greater Real-Life Diagnostic Efficacy of Allergen Molecule-Based Diagnosis for Prescription of Immunotherapy in an Area with Multiple Pollen Exposure [J]. Int Arch Allergy Immunol,2017,173(2):93-98.
[5] Hamilton RG,Kleine-Tebbe J. Molecular Allergy Diagnostics:Analytical Features That Support Clinical Decisions [J]. Curr Allergy Asthma Rep,2015,15(9):57.
[6] 许志强,魏继福.过敏原组分解析诊断在过敏疾病中的应用进展[J].临床药物治疗杂志,2019,17(1):18-22.
[7] Zhao L,Fu W,Gao B,et al. Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens [J]. Clin Transl Allergy,2020,10(1):50.
[8] Gao Z,Fu WY,Sun Y,et al. Artemisia pollen allergy in China:Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization [J]. Allergy,2019,74(2):284-293.
[9] 付婉艺.中国蒿属花粉过敏原分子生物学分析和组分诊断[D].杭州:浙江大学,2018.
[10] 娄鸿飞,马思远,赵岩,等.北京地区变应性鼻炎患者的优化吸入过敏原谱研究[J].临床耳鼻咽喉头颈外科杂志,2018,32(1):37-42.
[11] 侯红枝,郑艳秋.内蒙古中西部地区变应性鼻炎疑似患者变应原分布的分析[J].中国眼耳鼻喉科杂志,2019, 19(1):22-25.
[12] 萨日娜,李晓安,王雨朦,等.内蒙古鄂尔多斯地区1440例过敏性鼻炎患儿过敏原检测结果分析[J].中国中西医结合儿科学,2021,13(1):89-92.
[13] 萨日娜.内蒙古地区过敏性鼻炎流行病学调查研究[D].呼和浩特:内蒙古医科大学,2020.
[14] 宋柏龙,许栋岳,马智杰,等.内蒙古地区花粉观察及变应性鼻炎的防治分析[J].中国医学文摘:耳鼻咽喉科学,2019,34(3):174-176,180.
[15] 李静,孟春明,胡学莲,等.儿童花粉症研究进展[J].中国医药科学,2020,10(18):53-56.
[16] Schenk MF,Cordewener JH,America AH,et al. Proteomic analysis of the major birch allergen Bet v1 predicts allergenicity for 15 birch species [J]. J Proteomics,2011, 74(8):1290-1300.
[17] Ebo DG,Hagendorens MM,Bridts CH,et al. Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein proflin:mimickers of llrgy [J]. Clin Exp Allery,2010,34(1):137-144.
[18] Stringani G,Tipodi S,affareli C,et al. The efecet of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever [J]. J Allergy Clin Immunol,2014,134(1):75-81.
[19] Bokanovic D,Aberer W,Hemmer W,et al. Determination of sIgE to rPhl p1 is sufficient to diagnose grass pollen allergy [J]. Allergy,2013,68(11):1403-1409.
[20] Sander L,Rozynek P,Rihs HP,et al. Multiple wheat flour allergens and cross-Teactive carbohydrate determinants bind IgE in baker’s asthmal [J]. Allergy,2011,66(9):1208-1215.
[21] Gomez-Casado C,Garndo-Arandia M,Pereira C,et al. Compornent-resolved diagnosis of wheat flour allergy in baker’s asthma [J]. Allergy Clin Immunol,2014,134(2):480-483.
[22] 姚丽娜.应用容量法监测花粉浓度及花粉过敏原交叉反应的研究[D].北京:中国协和医科大学,2009.
[23] 王晓艳,丁佳琪,陈艳蕾,等.豚草花粉在夏秋季花粉症中的致敏特点分析[J].中国耳鼻咽喉头颈外科,2020, 27(4):180-183.
[24] 吴晓蔓,黄妩姣.艾蒿花粉与豚草花粉的抗原成分分析[J].广东医学,2004,25(10):1136-1138.
[25] Pablos I,Eichhorn S,Briza P,et al. Proteomic profiling of the weed feverfew,a neglected pollen allergen source [J]. Sci Rep,2017,7(1):6049.
[26] 叶荪.花粉-植物性食物交叉过敏反应原理[J].中国社区医师,2018,34(6):8-10.
[27] 邓珊.中国人群蒿花粉相关食物过敏精准诊断的研究[D].北京:北京协和医学院,2016.
[28] Matneardi PM,Klrinn-Tehbe J,Hoffmana HJ,et al. EAACI molecular allergology user’s guide [J]. Prediatr Allergy Immunol,2016,27(Suppl 23):1-236.
[29] 张立营,赵权.Ⅰ型变态反应过敏原体外诊断现状[J].中国疗养医学,2019,28(9):940-941.
[30] Wang L,Zhang X,Zhang J,et al. Proteomic Analysis and Identification of Possible Allergenic Proteins in Mature Pollen of Populus tomentosa [J]. Int J Mol Sci,2018,19(1):250.
[31] Raulf M. Allergen component analysis as a tool in the diagnosis and management of occupational allergy [J]. Mol Immunol,2018,100:21-27.
[32] Cipriani F,Mastrorilli C,Tripodi S,et al. Italian Pediatric Allergy Network (I-PAN). Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules [J]. Allergy,2018,73(3):673-682.