Abstract：Objective To study the application effect of Ambroxol Hydrochloride in nasal endoscopy after chronic sinusitis with nasal polyp. Methods A total of 210 patients with chronic sinusitis complicated with nasal polyps in the Affiliated Huaian NO.1 People’s Hospital of Nanjing Medical University from January 2017 to January 2020 were selected as the research subjects, and they were divided into observation group and control group according to random number table method, with 105 cases in each group. Both groups received endoscopic sinus surgery, the control group received conventional glucocorticoids after surgery, and the observation group was additionally given Ambroxol Hydrochloride, Both groups lasted for one month. The clinical efficacy of the two groups was compared. Symptom scores and serum levels of procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were compared between the two groups before and after treatment. The recurrence of nasal polyp in two groups was recorded within one year. Results After treatment, the total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, the scores of nasal obstruction, runny nose, and olfactory disorder in two groups were lower than those before treatment, and the observation group was significantly lower than the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of PCT, hs-CRP, and IL-6 in two groups were significantly decreased compared with before treatment, and the observation group was significantly lower than the control group, the differences were statistically significant (P ＜ 0.05). One year after treatment, the recurrence rate of nasal polyp in the observation group was significantly lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Ambroxol Hydrochloride is effective in the treatment of chronic sinusitis complicated with nasal polyp, which can improve nasal congestion and other symptoms and reduce the risk of nasal polyp recurrence.
[1] Taha MS，Nocera A，Workman A，et al. P-glycoprotein inhibition with verapamil overcomes mometasone resistance in Chronic Sinusitis with Nasal Polyps [J]. Rhinology，2021，59（2）：205-211.
[2] Izadi N，Bauman BM，Dabbah G，et al. CADINS in an Adult with Chronic Sinusitis and Atopic Disease [J]. J Clin Immunol，2020，41（4）：256-258.
[3] Elkalla RA，Nossier A，Millar AL，et al. Intraoral Dual Wavelength Laser Diode Therapy for Chronic Maxillary Sinusitis [J]. Laser Therapy，2020，29（1）：35-40.
[4] Sher MR，Steven GC，Romett JL，et al. EXHANCE-3： a cohort study of the exhalation delivery system with fluticasone for chronic sinusitis with or without nasal polyps [J]. Rhinology，2020，58（1）：25-35.
[5] Podwysocka M，D?諭browska K，Fendler W，et al. Analysis of the impact of bronchial asthma and hypersensitivity to aspirin on the clinical course of chronic sinusitis with nasal polyps [J]. Otolaryngol Pol，2019，73（5）：37-43.
[6] 何恒胜，黄河银，兰建滨.枸地氯雷他定辅助治疗对慢性鼻窦炎鼻窦内窥镜手术患者血清炎性因子及鼻黏液纤毛清除功能的影响[J].实用医院临床杂志，2019，16（6）：105-108.
[7] 中华耳鼻咽喉头颈外科杂志编委会，中华医学会耳鼻咽喉头颈外科学分会鼻科学组.慢性鼻-鼻窦炎诊断和治疗指南[J].中国临床医生杂志，2010，38（8）：21-22.
[8] 雍军，王咏峰.鼻渊通窍颗粒联合曲安奈德鼻喷雾剂治疗慢性鼻-鼻窦炎的临床观察[J].中国药房，2016，27（20）：2795-2797.
[9] 甄甄，廖波，李志勇，等.慢性鼻-鼻窦炎患者嗅觉障碍影响因素分析[J].临床耳鼻咽喉头颈外科杂志，2014，28（17）：1282-1284.
[10] Olszewska A，Niewiadomski P，Olszewski J. Influence of nasal mucosa irritants on the occurrence of chronic sinusitis without/and with polyps [J]. Otolaryngol Pol，2020， 74（4）：1-5.
[11] Ikeda M，Iwahashi C，Hirai T，et al. A Case of Eosinophilic Chronic Rhinosinusitis Associated with Choroidal Folds and Ocular Motility Disorder [J]. Case Rep Ophthalmol，2019，10（1）：89-94.
[12] Antonio MA，Marson FAL，Toro MDC，et al. Topical tretinoin in chronic rhinosinusitis with nasal polyps：a randomized clinical trial [J]. Int Forum Allergy Rhinol，2021，11（8）：1187-1196.
[13] Craig JR，Mchugh CI，Griggs ZH，et al. Optimal timing of endoscopic sinus surgery for odontogenic sinusitis [J]. Laryngoscope，2019，129（9）：1976-1983.
[14] 王桂芳，黄观辉，谢红冠.克拉霉素联合盐酸氨溴索治疗成人急性副鼻窦炎[J].中国临床研究，2019，32（9）：106-108.
[15] 陈亮，李健忠，梁云燕，等.鼻窦球囊扩张术联合清窦通窍方口服+熏蒸对慢性鼻-鼻窦炎患者嗅觉，鼻通气鼻黏膜纤毛清除能力的影响及机制探讨[J].现代中西医结合杂志，2019，28（9）：31-35.
[16] Ali YH，Alandejani T. Rhinoplasty Assisted by Endoscopic Septoplasty：Precise Job and an Educational Tool [J]. J Craniofac Surg，2020，31（3）：847-850.
[17] 王周美，李勇，杨杭.变应性鼻炎患者血清IL-34水平及与血清炎症因子的相关性[J].中国现代医学杂志，2019， 29（18）：82-85.
[18] 郝娟，陈旭婷，杨慧，等.盐酸氨溴索治疗新生儿肺炎的临床价值研究及对预后影响[J].药物评价研究，2019， 42（5）：149-152.
[19] 王侃，赵白云，缪晓青，等.盐酸氨溴索辅助治疗新生儿感染性肺炎的疗效与相关药理机制研究[J].中华医院感染学杂志，2019，29（11）：123-126.
[20] 朱建凤，王红娟.盐酸氨溴索联合纤维支气管镜肺泡灌洗在老年重症肺炎患者中的应用效果[J].实用临床医药杂志，2020，24（1）：82-87.
[21] 秦岭，聂文婷.宣化降平清利汤联合盐酸氨溴索治疗慢性支气管炎患者的临床效果[J].世界中医药，2020，15（14）：2109-2111.
[22] 梁蔚繁.盐酸氨溴索联合噻托溴铵治疗急性期老年慢性阻塞性肺疾病的临床效果[J].中国医药，2020，15（6）：70-74.
[23] 董永超，李想，程超.盐酸氨溴索联合盐酸丙卡特罗治疗儿童支气管肺炎的疗效及安全性分析[J].中国医药科学，2021，11（9）：75-78.
[24] 何伟，李儒佑.中西医结合对老年重症肺炎患者临床疗效及血清学指标的影响[J].西部中医药，2020，33（2）：95-98.
[25] Kim JY，Cha MJ，Park YS，et al. Upregulation of FZD5 in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Epigenetic Modification [J]. Mol Cells，2019，42（4）：345-355.
[26] 杨芳芳，尚朋娟.盐酸氨溴索联合常规治疗对新生儿肺炎的支气管黏膜纤毛结构及炎性因子的影响[J].河北医科大学学报，2019，40（2）：111-114.
[27] 梁卫勤，林智.鼻窦内镜术辅助盐酸氨溴索治疗老年慢性鼻窦炎伴鼻息肉的疗效及对血清IL-6、IL-17、IL-23表达的影响[J].中国老年学杂志，2020，40（12）：2610-2613.
[28] 王雅堂，杨见明，许海艳.鼻内镜手术联合糖皮质激素浸润对慢性鼻窦炎伴鼻息肉患者远期疗效及鼻功能的影响[J].中国现代医学杂志，2020，30（10）：87-91.
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