Effect of Dingchen Fuzheng Decoction on gastrointestinal function recovery and Th1/Th2 immune drift after operation of digestive system malignant tumor#br#
GAO Xiaojie1 CHEN Juan2 ZHANG Jing1 HAO Jianwen1
1.Department of Rehabilitation Medicine, Hebei General Hospital for Veterans, Hebei Province, Xingtai 054000, China;
2.Department of Traditional Chinese Medicine, Xingtai Traditional Chinese Medicine Hospital, Hebei Province, Xingtai 054001, China
Abstract:Objective To investigate the effect of Dingchen Fuzheng Decoction on gastrointestinal function recovery and Th1/Th2 immune drift after operation of digestive system malignant tumor. Methods A total of 120 patients with digestive system malignant tumor who underwent surgical treatment in Hebei General Hospital for Veterans from January 2018 to December 2019 were selected and they were divided into observation group and control group according to random number table method, with 60 cases in each group. The observation group was treated with basic treatment and Dingchen Fuzheng Decoction, while the control group was treated with basic treatment and Motilium. After one month of treatment, the postoperative indexes, motilin, vasoactive intestinal peptide, cytokine levels and type 1 helper T cells/type 2 helper T cells (Th1/Th2) levels of the two groups were observed. Results The recovery time of bowel sound, postoperative first exhaust time, postoperative first defecation time and postoperative total flow recovery time in the observation group were lower than those in the control group (P < 0.01). One month after surgery, motilin levels in both groups were increased and vasoactive peptide levels were decreased compared with one day after surgery, and the motilin level in observation group was higher than that in control group, while vasoactive peptide level was lower than that in control group (P < 0.05). One month after surgery, the levels of interleukin (IL)-2 in the two groups were increased and the levels of IL-4, IL-6, and interferon -γ (IFN-γ) were decreased compared with that one day after surgery, and the level of IL-2 in the observation group was higher than the control group. The levels of IL-4, IL-6, and IFN-γ were lower than those of control group (P < 0.05). The Th1/Th2 level in the observation group was significantly higher than that in the control group one month after surgery (P < 0.05). The total incidence of postoperative complications in the observation group was lower than that in the control group (P < 0.01). Conclusion Dingchen Fuzheng Decoction has a good effect on gastrointestinal dysfunction after operation of digestive system malignant tumor, and can improve Th1/Th2 drift.