血尿酸、CysC及Hcy与老年帕金森病患者病程及疾病严重程度相关性分析

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摘要目的分析血尿酸（UA）、胱抑素C（CysC）及同型半胱氨酸（Hcy）与老年帕金森病患者病程及疾病严重程度的相关性。方法选取2018年1月至2021年1月南通大学附属瑞慈医院收治的86例老年帕金森病患者。按照病程分为<6年组（45例），6~10年组（28例）和>10年组（13例）；按照Hoehn-Yahr分级评分量表分为轻度组（25例），中度组（43例）和重度组（18例）。比较不同病程和不同病情严重程度患者血清UA、CysC和Hcy水平，采用Spearman相关分析血清UA、CysC、Hcy水平与病程、疾病严重程度的相关性。结果 >10年组血清UA水平低于6~10年组、<6年组；6~10年组血清UA水平低于<6年组，差异有统计学意义（P < 0.05）。>10年组血清CysC和Hcy水平高于6~10年组、<6年组；6~10年组血清CysC和Hcy水平高于<6年组，差异有统计学意义（P < 0.05）。重度组血清UA水平低于中度组、轻度组；中度组血清UA水平低于轻度组，差异有统计学意义（P < 0.05）。重度组血清CysC和Hcy水平高于中度组、轻度组；中度组血清CysC和Hcy水平高于轻度组，差异有统计学意义（P < 0.05）。血清UA水平与病程呈负相关（P < 0.05）；血清CysC、Hcy水平与病程、疾病严重程度呈正相关（P < 0.05）。结论老年帕金森病不同病程和不同病情严重程度患者血清UA、CysC、Hcy水平变化明显，临床监测其水平变化对于防治以及控制病情发展具有重要作用。

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	张家和1 柯开富2 施建生2 张骐1

关键词 ：帕金森病, 血尿酸, 胱抑素C, 同型半胱氨酸, 病程, 严重程度

Abstract：Objective To analyze the correlation of blood uric acid (UA), cystatin C (CysC), and homocysteine (Hcy) with the course and severity of disease in elderly patients with Parkinson disease. Methods Eighty-six elderly Parkinson disease patients admitted to Affiliated Ruici Hospital of Nantong University from January 2018 to January 2021 were selected. They were divided into <6 years group (45 cases), 6-10 years group (28 cases), and >10 years group (13 cases) according to the course of the disease; they were divided into mild group (25 cases), moderate group (43 cases), and severe group (48 cases) according to the Hoehn-Yahr grading scale. Serum UA, CysC, and Hcy levels in patients with different courses of disease and different severity of disease were compared, and the correlation between serum UA, CysC, and Hcy levels and the course of disease and severity of disease were analyzed by Spearman correlation analysis. Results The serum UA level in >10 years group was lower than that in 6-10 years group and <6 years group; the serum UA level in 6-10 years group was lower than that in <6 years group, and the differences were statistically significant (P < 0.05). The levels of serum CysC and Hcy in >10 years group were higher than those in 6-10 years group and <6 years group; and the levels of serum CysC and Hcy in 6-10 years group were higher than those in <6 years group, and the differences were statistically significant (P < 0.05). The serum UA level in severe group was lower than that in moderate group and mild group; the serum UA level in moderate group was lower than that in mild group, and the differences were statistically significant (P < 0.05). The levels of serum CysC and Hcy in severe group were higher than those in moderate group and mild group; and the levels of serum CysC and Hcy in moderate group were higher than those in mild group, and the differences were statistically significant (P < 0.05). Serum UA level was negatively correlated with the course of disease (P < 0.05); serum CysC and Hcy levels were positively correlated with the course of disease and severity of disease (P < 0.05). Conclusion The changes of serum UA, CysC, and Hcy levels in elderly patients with Parkinson disease with different course and severity of disease are significant, clinical monitoring of the changes of serum UA, CysC, and Hcy levels is of great importance for prevention and treatment and control of disease development.

Key words： Parkinson disease Uric acid Cystatin C Homocysteine Course of disease Severity

基金资助:江苏省自然科学基金委员会青年基金项目（BK 20161044）。

作者简介: 张家和（1967.12-），男，副主任医师；研究方向：脑血管疾病。

引用本文:

张家和1 柯开富2 施建生2 张骐1. 血尿酸、CysC及Hcy与老年帕金森病患者病程及疾病严重程度相关性分析[J]. 中国医药导报, 2022, 19(5): 82-85.
ZHANG Jiahe1 KE Kaifu2 SHI Jiansheng2 ZHANG Qi1. Correlation analysis of serum uric acid, CysC, and Hcy with the course and severity of disease in elderly patients with Parkinson disease#br#. 中国医药导报, 2022, 19(5): 82-85.

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