Abstract：Objective To investigate the effect of Chaihu plus Longgu Muli Decoction on patients with post-stroke depression with liver qi stasis. Methods A total of 114 patients with post-stroke depression with liver qi stasis admitted to the Second Hospital of Shijiazhuang from January 2019 to May 2020 were selected and divided into control group and observation group by random number table method, with 57 patients in each group. The control group was treated with Flupentixol and Melitracine Tablets on the basis of conventional treatment, and the observation group was treated with Chaihu plus Longgu Muli Decoction on the basis of conventional treatment. Both groups were treated for four weeks. The clinical efficacy and changes of plasma 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), and peripheral blood neutrophil to lymphocyte ratio (NLR) before and after treatment were observed. Hamilton depression scale (HAMD) and National Institutes of Health stroke scale (NIHSS) scores were compared between the two groups before and after treatment. Results The total effective rate of observation group was higher than that of control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of plasma 5-HT and BDNF were higher than before treatment, and the NLR in peripheral blood, HAMD, and NIHSS scores in peripheral blood were lower than those before treatment, and the plasma 5-HT and BDNF levels in the observation group were higher than those in the control group, and the NLR in peripheral blood, HAMD, and NIHSS scores were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Chaihu plus Longgu Muli Decoction has a significant effect in the treatment of post-stroke depression with liver qi stasis, which can quickly relieve the clinical symptoms of patients, and is worth promoting.
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