Research progress of deoxyribonuclease 1 analogue 3 in autoimmune diseases #br#
OUYANG Bohui
Department of Clinical Laboratory, Third Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Liuzhou 545001, China
Abstract：Autoimmune disease is a disease with high morbidity and fatality rate, since its morbidity is on the rise globally, its early diagnosis is particularly important. Deoxyribonucinase 1 analogue 3 (DNASE1L3) is an endonuclionase that degrades the chromatin of apoptotic or necrotic cells. Its deletion or accumulation leads to disorder in the clearance of apoptotic cells in vivo, triggering autoimmune reactions and causing autoimmune diseases. Especially, its expression level and mechanism in systemic lupus erythematosus, ankylosing spondylitis, dermatomyositis and polymyositis, and other autoimmune diseases have attracted much attention. In addition, the expression of DNASE1L3 is also different in malignant tumors and respiratory diseases. This means that it has a good clinical guiding significance for the diagnosis, treatment and prognosis of these diseases. This article reviews the application and research progress of DNASE1L3 in autoimmune diseases and other diseases in recent years.
[1] Zhao Q，Yang C，Wang J，et al. Serum level of DNase1l3 in patients with dermatomyositis/polymyositis，systemic lupus erythematosus and rheumatoid arthritis，and its association with disease activity[J]. Clin Exp Med，2017，17（4）： 459-465.
[2] Keyel PA. Dnases in health and disease [J]. Dev Biol，2017，429（1）：1-11.
[3] Napirei M，Ludwig S，Mezrhab J，et al. Murine serum nucleases--contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3（DNase1l3）[J]. Febs j，2009，276（4）：1059-1073.
[4] 史曼.巨噬细胞极化与肿瘤的发展[J].科学技术创新，2019（20）：16-17.
[5] Kalaaji M，Mortensen E，J?覬rgensen L，et al. Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells [J]. Am J Pathol，2006，168（6）：1779-1792.
[6] Al-Mayouf SM，Sunker A，Abdwani R，et al. Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus [J]. Nat Genet，2011，43（12）：1186-1188.
[7] 程佑，杨艳，王明华.40例多发性肌炎/皮肌炎病人的临床特点分析[J].安徽医药，2019，23（2）：283-286.
[8] 谭艳平，刘志刚.皮肌炎/多发性肌炎病因及发病机制的研究进展[J].中国皮肤性病学杂志，2016，30（6）：634-636，649.
[9] Higgs BW，Liu Z，White B，et al. Patients with systemic lupus erythematosus，myositis，rheumatoid arthritis and scleroderma share activation of a common typeⅠinterferon pathway [J]. Ann Rheum Dis，2011，70（11）：2029-2036.
[10] 贾连玲，王欣茹，白静，等.强直性脊柱炎患者HLA-B27抗原、ESR、CRP等检测指标水平分析及临床意义[J].国际检验医学杂志，2018，39（2）：243-245.
[11] Sharma N，Sharma V，Masood T，et al. Usage of Conventional PCR Technology for the Detection of HLA-B27 Allele： A Significant Molecular Marker of Ankylosing Spondylitis [J]. Indian J Clin Biochem，2013，28（2）：189-192.
[12] Sun Y，Ouyang B，Xie Q，et al. Serum Deoxyribonuclease 1-like 3 is a potential biomarker for diagnosis of ankylosing spondylitis [J]. Clin Chim Acta，2020，503：197-202.
[13] Zochling J，Newell F，Charlesworth JC，et al. An Immu-nochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3 [J]. Arthritis Res Ther，2014，16（5）：438.
[14] Mayes MD，Bossini-Castillo L，Gorlova O，et al. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis [J]. Am J Hum Genet，2014，94（1）： 47-61.
[15] Tsou PS，Sawalha AH. Unfolding the pathogenesis of scleroderma through genomics and epigenomics [J]. J Autoimmun，2017，83：73-94.
[16] Oz?觭akar ZB，Foster J，Diaz-Horta O，et al. DNASE1L3 mutations in hypocomplementemic urticarial vasculitis syndrome [J]. Arthritis Rheum，2013，65（8）：2183-2189.
[17] Carbonella A，Mancano G，Gremese E，et al. An autosomal recessive DNASE1L3-related autoimmune disease with unusual clinical presentation mimicking systemic lupus erythematosus [J]. Lupus，2017，26（7）：768-772.
[18] 陈国军，杨中汉，冯娟.1型糖尿病的免疫机制研究进展[J].中国医药导报，2017，14（32）：39-42.
[19] Westra HJ，Martínez-Bonet M，Onengut-Gumuscu S，et al. Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes [J]. Nat Genet，2018，50（10）：1366-1374.
[20] Bhalla S，Chaudhary K，Kumar R，et al. Gene expression-based biomarkers for discriminating early and late stage of clear cell renal cancer [J]. Sci Rep，2017，7： 44997.
[21] Shim JH，Yoon DL，Han S，et al. Is serum alpha-fetoprotein useful for predicting recurrence and mortality specific to hepatocellular carcinoma after hepatectomy? A test based on propensity scores and competing risks analysis [J]. Ann Surg Oncol，2012，19（12）：3687-3696.
[22] 瞿兵，陈鹏飞，李希平.脱氧核糖核酸酶1类似物3基因表达与肝癌临床病理特征及预后的相关性[J].中国生物制品学杂志，2018，31（7）：718-722.
[23] Wang S，Ma H，Li X，et al. DNASE1L3 as an indicator of favorable survival in hepatocellular carcinoma patients following resection [J]. Aging （Albany NY），2020，12（2）：1171-1185.
[24] 张俊卿.MMP1、Dnase1L3在口腔疣状癌中的表达研究[D].长沙：中南大学，2012.
[25] Wang K，Gao M，Yang M，et al. Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency [J]. Hum Genomics，2017，11（1）：4.
[26] Sánchez-Ovando S，Baines KJ，Barker D，et al. Six gene and TH2 signature expression in endobronchial biopsies of participants with asthma [J]. Immun Inflamm Dis，2020，8（1）：40-49.
[27] Fricker M，Gibson PG，Powell H，et al. A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma [J]. J Allergy Clin Immunol，2019，144（1）：51-60.
[28] Berthon BS，Gibson PG，Wood LG，et al. A sputum gene expression signature predicts oral corticosteroid response in asthma [J]. Eur Respir J，2017，49（6）：1700180.
[29] 李光韬，张卓莉.自身免疫性疾病与发热[J].中国实用内科杂志，2016，36（12）：1032-1035.
[30] 赵丹，杨小猛，马文松，等. HLA-B27阳性类风湿关节炎和强直性脊柱炎患者外周血T细胞亚群分析[J].国际检验医学杂志，2011，32（2）：150-151，153.
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