Abstract：Objective To explore the correlation between homocysteinemia (HCY), glutamyltransferase (GGT) and coronary heart disease and the degree of coronary artery stenosis. Methods Patients who underwent coronary angiography in the Second People′s Hospital of Hefei from October 2015 to October 2016 were selected randomly as the research subjects. They were divided into normal group (115 cases) and coronary heart disease group (161 cases) based on the results of diagnostic coronary angiography. Results The two groups had significant differences in age, hypertension history, triacylglycerol, total cholesterol, high-density lipoprotein chdesterol, low density lipoprotein, apolipoprotein A, apolipoprotein B, uric acid, total bilirubin, indirect bilirubin, HCY and GGT (P ＜ 0.05). According to linear correlation analysis, the levels of HCY and GGT were positively correlated with coronary Gensini scores (r = 2.18, 2.42, P ＜ 0.05). Multivariate Logistic regression analysis showed that HCY and GGT were independent risk factors of coronary heart disease (P ＜ 0.01, 95%CI: 1.035-1.167; P ＜ 0.01, 95%CI: 1.083-1.175). In a receiver operating characteristic (ROC) curve, the HCY value of 11.80 mmol/l was identified as an effective cut-point in the coronary heart disease and the area under curve was 0.686. Conclusion HCY and GGT are independent risk factors of coronary heart disease and they are positively correlated with the degree of coronary artery stenosis. HCY is an indicator of diagnosis of coronary heart disease.
陈敏 杨林飞 孙桂兰 高玉. 血清同型半胱氨酸、谷氨酰转移酶与冠心病及冠脉狭窄程度的相关性[J]. 中国医药导报, 2018, 15(26): 50-53.
CHEN Min YANG Linfei SUN Guilan GAO Yu. Correlation between homocysteinemia, glutamyltransferase and coronary heart disease and the degree of coronary artery stenosis. 中国医药导报, 2018, 15(26): 50-53.
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2018, Vol. 15 
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