Abstract：Objective To investigate the relationship between changes of immune function and liver function damage in children with infectious mononucleosis (IM), so as to provide a theoretical basis for prevention and treatment of liver damage. Methods Clinical data of 85 children with IM caused by Epstein-Barr virus infection in the First People’s Hospital of Lianyungang, Jiangsu Province, from July 2017 to July 2019 were selected. They were divided into liver function damage group and no liver function damage group, according to whether the occurrence of liver function damage. The expression of IgA, IgM, IgG, CD19+B lymphocyte, complement component C3, natural killer (NK) cell, T lymphocyte subsets (CD4+, CD8+, and CD4+/CD8+) were compared between two groups; and the correlation between immune function and liver function damage in children with IM was analyzed. Results The incidence of IM children complicated with liver function damage was 40% (34/85). There were statistically significant differences in IgA, IgG, IgM, CD19+, CD8+, CD4+, CD4+/CD8+, and complement C3 between two groups (P < 0.05); there was no significant difference between two groups (P > 0.05). ALT level had no correlation with IgA, IgG, IgM, CD19+, CD8+, CD4+, CD4+/CD8+, and complement C3 (P > 0.05). CD8+ was an independent risk factor for liver function damage in IM children (OR = 1.104, P < 0.05). Conclusion The disorder of immune system in IM children is associated with liver function damage, so it is necessary to strengthen the monitoring of the disorder of immune function in IM children, and give liver protection and immunomodulatory therapy in early stage.
刘姜艳 孙军▲ 茆康卫 李大雷. 儿童传染性单核细胞增多症免疫功能变化与肝功能损害相关性研究[J]. 中国医药导报, 2022, 19(3): 91-94.
LIU Jiangyan SUN Jun▲ MAO Kangwei LI Dalei. Correlation study on changes of immune function and liver damage in children with infectious mononucleosis#br#. 中国医药导报, 2022, 19(3): 91-94.
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