Clinical effect of the method of invigorating spleen and tonifying kidney on acquired immunodeficiency syndrome patients#br#
WANG Yinglin1 LIU Jianzhong1 XIAO Mingzhong1 NI Wei1 CHEN Yao1 YU Xiaoli2 YUN Fan3 KE Jingwen3
1.Hubei Provincial Hospital of Traditional Chinese Medicine Hubei Province Academy of Traditional Chinese Medicine the Affiliated Hospital of Hubei University of Chinese Medicine, Hubei Province, Wuhan 430061, China;
2.Wuhan Infectious Disease Hospital, Hubei Province, Wuhan 430022, China;
3.School of Clinical Medicine, Hubei University of Chinese Medicine, Hubei Province, Wuhan 430065, China
Abstract：Objective To observe the clinical effect of the method of invigorating spleen and tonifying kidney on acquired immunodeficiency syndrome patients. Methods A total of 32 acquired immunodeficiency syndrome patients with incomplete immune reconstitution and deficiency of spleen and kidney in Wuhan Infectious Disease Hospital from January 2017 to December 2020 were selected as research subjects, and they were divided into treatment group and control group according to random number table method, with 16 cases in each group. Sixteen patients in the treatment group were treated with highly active anti-retroviral therapy (HAART) + Jianpi Bushen Mianjian Granules, and sixteen patients in the control group were treated with HAART+Jianpi Bushen Mianjian Granule Simulation Agents. Both groups were treated for 48 weeks. The liver and kidney function, traditional Chinese medicine symptom and sign score, Karofsky score and immunological indexes of the two groups were observed before and after treatment. Results There was no significant difference in liver and kidney function between the two groups after treatment and before treatment (P ＞ 0.05). After treatment, the scores of traditional Chinese medicine symptoms and signs in the two groups were lower than those before treatment, and which in the treatment group were lower than those in the control group (P ＜ 0.05). After treatment, the Karofsky score in the treatment group was higher than that before treatment, and that in the treatment group was higher than that in the control group (P ＜ 0.05). After treatment, the proportion of CD4+CD45RA+T cells and the ratio value of CD4+CD45RA+T cells to CD4+CD45RO+T cells in the treatment group were higher than those before treatment, and those in the treatment group were higher than those in the control group (P ＜ 0.05). After treatment, the proportion of CD4+CD45RO+T cells in the treatment group was lower than that before treatment, and that in the treatment group were higher than the control group (P ＜ 0.05). Conclusion Invigorating spleen and tonifying kidney method has a good safety in the treatment of acquired immunodeficiency syndrome patients with incomplete immune reconstitution and deficiency of spleen and kidney, improving the quality of life of patients, improving the immune function of the body, showing a good synergistic effect.
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