Clinical characteristics of adenovirus pneumonia and respiratory syncytial virus pneumonia in children#br#
YANG Yan1 ZHANG Yang2 HUANG Juan1 ZHAN Xiaoyun1 ZHAO Alan1 WU Bei1 LU Yinghong1▲
1.Department of Pediatric Hematology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan 430070, China;
2.Department of General Surgery, Central Theater General Hospital, Chinese People’s Liberation Army, Hubei Province, Wuhan 430070, China
Abstract：Objective To analyze the clinical characteristics of adenovirus (ADV) and respiratory syncytial virus (RSV) infection in hospitalized children with pneumonia, and to provide reference for clinical diagnosis and treatment. Methods Retrospective analysis from January to December 2019, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology of the clinical data of children with simple ADV pneumonia and simple RSV pneumonia, including general situation, clinical manifestations, early course of laboratory examination and imaging examination, severe or very severe pneumonia, respiratory support, and hospital stay. Results Among 102 cases of pneumonia, 36 cases were simple ADV pneumonia and 66 cases were simple RSV pneumonia. There was no significant difference in gender between two groups (P > 0.05). The age of onset in ADV group was significantly higher than that in RSV group (P < 0.05). There was statistical significance in onset seasons between two groups (P < 0.05). The course of heat of ADV group was longer than that of RSV group, the proportion of fever ≥39.0℃ was higher than that of RSV group, the incidence of expectoration, moist rale, and wheezing sound were lower than those of RSV group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of gasping and inspiratory three concave sign between two groups (P > 0.05). There was no significant difference in white blood cell count between two groups (P > 0.05). The percentage of neutrophil, C-reactive protein level, and the proportion of procalcitonin > 0.1 ng/ml in ADV group were higher than those in RSV group; the percentage of lymphocytes was lower than that in RSV group, and the differences were statistically significant (P < 0.05). There were no significant differences in lung imaging and imaging improvement rate after treatment between two groups (P > 0.05). There were no extremely severe pneumonia in both groups; there were no significant differences in the incidence of severe pneumonia between two groups (P > 0.05). There were no significant differences in oxygen rate, non-invasive respiratory support rate and hospital stay between two groups (P > 0.05). Conclusion ADV pneumonia should be considered in infants and preschool children with high fever, lung auscultation with only moist rale, neutrophil percentage, C-reactive protein and procalcitonin significantly increased, while RSV pneumonia should be considered in infants with obvious wheezing sound.
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