Abstract：Objective To explore the effect of different early interventional time on the prognosis of high risk patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods A total of 406 high-risk patients with NSTE-ACS admitted to the Department of Cardiology, Daxing District People’s Hospital of Beijing from January 2017 to December 2019 were enrolled. According to the different timing of percutaneous coronary intervention (PCI), the patients were divided into group A (incidence ＜12 hours) and group B (incidence 12-24 hours), and the incidence of major adverse cardiovascular events during hospitalization and one year after discharge were compared between the two groups. Results During hospitalization, and one year after discharge, the incidence of major adverse cardiovascular events in group A was significantly lower than group B (P ＜ 0.05). Conclusion For high-risk patients with NSTE-ACS, PCI therapy within 12 hours can significantly reduce the incidence of major adverse cardiovascular events during hospitalization and one year after discharge.
王文斌 闫明聪 程国杰 . 早期介入治疗对高危非ST段抬高型急性冠脉综合征患者预后的影响[J]. 中国医药导报, 2022, 19(2): 63-66.
WANG Wenbin YAN Mingcong CHENG Guojie. Effects of early intervention on the prognosis of patients with high risk non-ST -segment elevation acute coronary syndrome#br#. 中国医药导报, 2022, 19(2): 63-66.
[1] 师树田，聂绍平.2015ESC非ST段抬高型急性冠脉综合征管理指南解析[J].中国心血管病研究，2016，14（2）：116-118.
[2] Baumann AAW，Mishra A，Worthley MI，et al. Management of multivessel coronary artery disease in patients with non-ST-elevation myocardial infarction：a complex path to precision medicine [J]. Ther Adv Chronic Dis，2020，11：2040622320938527.
[3] Guedeney P，Collet JP. Diagnosis and Management of Acute Coronary Syndrome：What is New and Why? Insight From the 2020 European Society of Cardiology Guidelines [J]. J Clin Med，2020，9（11）：3474.
[4] Collet JP，Thiele H，Barbato E，et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation [J]. Eur Heart J，2021，42（14）：1289-1367.
[5] Kofoed KF，Kelb?覸k H，Hansen PR，et al. Early Versus Standard Care Invasive Examination and Treatment of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome [J]. Circulation，2018，138（24）：2741-2750.
[6] Mehran R，Rao SV，Bhatt DL，et al. Standardized bleeding definitions for cardiovascular clinical trials： a consensus report from the Bleeding Academic Research Consortium [J]. Circulation，2011，123（23）：2736-2747.
[7] Bahrmann P，Rach J，Desch S，et al. Incidence and distribution of occluded culprit arteries and impact of coronary collaterals on outcome in patients with non-ST-segment elevation myocardial infarction and early invasive treatment strategy [J]. Clin Res Cardiol，2011，100（5）：457-467.
[8] Nadarajah R，Gale C. The management of acute coronary syndromes in patients presenting without persistent ST-segment elevation：key points from the ESC 2020 Clinical Practice Guidelines for the general and emergency physician [J]. Clin Med（Lond），2021，21（2）：e206-e211.
[9] Desperak P，Hawranek M，G?諭sior P，et al. Long-term outcomes of patients with multivessel coronary artery disease presenting non-ST-segment elevation acute coronary syndromes [J]. Cardiol，2019，26（2）：157-168.
[10] Li Y，Wang C，Nan Y，et al. Early invasive strategy for non-ST elevation acute coronary syndrome： a meta-analysis of randomized，controlled trials [J]. J Int Med Res，2020，48（10）：300060520966500.
[11] Rajpurohit N，Garg N，Garg R，et al. Early versus delayed percutaneous coronary intervention for patients with non-ST segment elevation acute coronary syndrome： a meta-analysis of randomized controlled clinical trials [J]. Catheter Cardiovasc Interv，2013，81（2）：223-231.
[12] Milasinovic D，Milosevic A，Marinkovic J，et al. Timing of invasive strategy in NSTE-ACS patients and effect on clinical outcomes： A systematic review and meta-analysis of randomized controlled trials [J]. Atherosclerosis，2015，241（1）：48-54.
[13] Barbarawi M，Kheiri B，Zayed Y，et al. Meta-analysis of optimal timing of coronary intervention in non-ST-elevation acute coronary syndrome [J]. Catheter Cardiovasc Interv，2020，95（2）：185-193.
[14] Navarese EP，Gurbel PA，Andreotti F，et al. Optimal timing of coronary invasive strategy in non-ST-segment elevation acute coronary syndromes：a systematic review and meta-analysis [J]. Ann Intern Med，2013，158（4）：261-270.
[15] Navarese EP，De Servi S，Gibson CM，et al. Early vs. delayed invasive strategy in patients with acute coronary syndromes without ST-segment elevation：a meta-analysis of randomized studies [J]. QJM，2011，104（3）：193-200.
[16] Jobs A，Mehta SR，Montalescot G，et al. Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome：a meta-analysis of randomised trials [J]. Lancet，2017，390（10096）：737-746.
[17] Mehta SR，Granger CB，Boden WE，et al. Early versus delayed invasive intervention in acute coronary syndromes [J]. N Engl J Med，2009，360（21）：2165-2175.
[18] Roffi M，Patrono C，Collet JP，et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation：Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology（ESC） [J]. Eur Heart J，2016，37（3）：267-315.
[19] Camaro C，Damman P. Antithrombotic PreTreatment and Invasive Strategies in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome [J]. J Clin Med，2020， 9（8）：2578.
[20] 王珏雅，徐秀英，田俊平.急性冠脉综合征经皮冠状动脉介入治疗患者出院后血脂状况调查[J].临床和实验医学杂志，2020，312（8）：875-878.
[21] Badings EA，Hermanides RS，Van Der Sluis A，et al. Use，timing and outcome of coronary angiography in patients with high-risk non-ST-segment elevation acute coronary syndrome in daily clinical practice：insights from a ‘real world’ prospective registry [J]. Neth Heart J，2019，27（2）：73-80.
[22] 白中乐，陶海龙，邢军辉，等.非ST段抬高型心肌梗死患者介入治疗最佳时机选择与预后分析[J].中国循证心血管医学杂志，2017，9（8）：957-959.
[23] 王长亮，王荣欣，翟文亮.溶栓后即刻PCI与直接PCI对STEMI患者术后心室重构及心功能的对比研究[J].中国医药导报，2020，17（17）：62-66，83.
[24] Krackhardt F，Ko■ka V，Waliszewski M，et al. Unrestricted use of polymer-free sirolimus eluting stents in routine clinical practice [J]. Medicine （Baltimore），2020，99（8）：e19119.
[25] Bahit MC，Lopes RD，Clare RM，et al. Heart failure complicating non-ST-segment elevation acute coronary syndrome：timing，predictors，and clinical outcomes [J]. JACC Heart Fail，2013，1（3）：223-229.
京公网安备 11010502046598号