Abstract：Objective To observe the clinical efficacy of Theophylline Sodium Glycinate Sustained Release Tablets in the treatment of bronchial asthma and the impacts on oxidative stress. Methods A total of 105 cases with bronchial asthma admitted to Sinopharm Tongmei General Hospital from November 2018 to September 2020 were selected as the research objects, and they were divided into control group (52 cases) and study group (53 cases) according to the random number table method. The control group received conventional treatment, the study group received Theophylline Sodium Glycinate Sustained Release Tablets additionally, the treatment course was three months. The clinical efficacy, disappearing time of main clinical symptoms (cough, breathe heavily, lung moist rale, and lung wheezing), pulmonary function (forced expiratory volume in one second [FEV1], FEV1/FVC, peak expiratory flow [PEF]), and oxidative stress indexes (malondialdehyde [MDA], lipid peroxide [LPO], reduced glutathione [GSH], and superoxide dismutase [SOD]) were compared, the adverse reactions were recorded. Results There was no significant difference in the total effective rate between the two groups (P ＞ 0.05). The disappearance time of cough, breathe heavily, lung moist rale, and lung wheezing in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05). After treatment, FEV1, FEV1/FVC, PEF, GSH, and SOD increased, while MDA and LPO decreased compared with before treatment in two groups (P ＜ 0.05). FEV1, FEV1/FVC, PEF, and SOD in the observation group were higher than those in the control group, while MDA and LPO were lower than those in the control group, the differences were statistically significant (P ＜ 0.05), while GSH between the two groups showed no significant difference (P ＞ 0.05). There were no obvious adverse reactions in both groups. Conclusion Theophylline Sodium Glycinate Sustained Release Tablets combined with conventional treatment are effective and safe for patients with bronchial asthma, and could decrease the oxidative stress injury.
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