Clinical significance and changes of microinflammatory factor, calcium and phosphorus metabolism levels in patients with chronic kidney disease and cardiac insufficiency#br#
SHEN Yuxin WANG Yangyang DENG Wenyan ZHANG Jing▲
Department of Intrarenal Rheumatology, the Fourth Affiliated Hospital of Anhui Medical University, Anhui Province, Hefei 230001, China
Abstract：Objective To study the clinical significance and changes of microinflammatory factor, calcium and phosphorus metabolism levels in patients with chronic kidney disease and cardiac insufficiency, and to provide guidance for clinical research. Methods A total of 85 patients with chronic kidney disease and cardiac insufficiency admitted to the Fourth Affiliated Hospital of Anhui Medical University from March 2018 to March 2020 were selected, according to the estimated glomerular filtration rate level of patients, they were divided into chronic kidney disease stage 1-2 group (14 cases), chronic kidney disease stage 3 group (22 cases), chronic kidney disease stage 4 group (23 cases), and chronic kidney disease stage 5 group (26 cases), and 30 healthy subjects were selected as control group during the same period. Serum fibrinogen (FIB), procalcitonin (PCT), and hypersensitive C-reactive protein (hs-CRP) were detected by enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetry. Blood phosphorus (P), blood calcium (Ca) and parathyroid hormone (PTH) were detected by automatic biochemical analyzer. The correlation between microinflammatory state and calcium and phosphorus metabolism was analyzed. Results The levels of FIB, PCT, and hs-CRP in the groups of chronic kidney disease stage 1-2, 3, 4, and 5 groups were significantly higher than those in the control group, the differences were statistically significant (P ＜ 0.05). The level of PCT in chronic kidney disease stage 4 group was significantly higher than that in the chronic kidney disease stage 1-2 group and 3 group, the levels of PCT and hs-CRP in the chronic kidney disease stage 5 group were significantly higher than those in chronic kidney disease stage 1-2 group, 3 group and 4 group, the differences were statistically significant (P ＜ 0.05). The levels of P and PTH in chronic kidney disease stage 1-2 group, 3 group, 4 group, and 5 group were higher than those in control group, the levels of Ca in chronic kidney disease stage 1-2 group and 3 group were lower than those in control group, and the level of PTH in chronic kidney disease 3 group was significantly higher than those in chronic kidney disease stage 1 group and 2 group. The levels of PTH and Ca in chronic kidney disease stage 4 group were significantly higher than those of chronic kidney disease stage 1-2 group, and 3 group, the levels of P and PTH in chronic kidney disease stage 5 group were higher than those in the chronic kidney disease stage 1-2 group, 3 group, and 4 group, level of Ca in chronic kidney disease stage 5 group was significantly higher than those of chronic kidney disease stage 3 group and 4 group, the differences were statistically significant (P ＜ 0.05). There was significant positive correlation between PCT level and P, PTH level, and significant negative correlation between PCT levels and Ca level (r = 0.614, 0.502, -0.551, P ＜ 0.001). hs-CRP was positively correlated with P and PTH levels, and negatively correlated with Ca level (r = 0.521, 0.518, -0.426, P ＜ 0.001). Conclusion Patients with chronic kidney disease and cardiac insufficiency have a micro-inflammatory state, abnormal calcium, and phosphorus metabolism levels, and their micro-inflammatory state may be related to calcium and phosphorus metabolism.
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