Abstract：Objective To explore the effect of Conbercept Injection combined with 532 nm laser panretinal photocoagulation in the treatment of diabetic retinopathy (DR) and its influence on fundus microcirculation. Methods Eighty-two patients (96 eyes) with DR admitted to the Ninth People’s Hospital of Suzhou City from March 2017 to March 2020 were selected and they were divided into observation group (41 cases, 50 eyes) and control group (41 cases, 46 eyes) according to the random number table method. The control group was treated with 532 nm laser panretinal photocoagulation, and the observation group was treated with Conbercept Injection on the basis of the control group. Retinal fovea thickness (CMT), best corrected visual acuity (BCVA), intraocular pressure, clinical efficacy, and fundus microcirculation were compared between the two groups. Results There were no significant differences in CMT, BCVA, and intraocular pressure between the two groups before treatment (P ＞ 0.05); six months after treatment, CMT in both groups was decreased, and the observation group was lower than that of the control group (P ＜ 0.05), BCVA was increased, and the observation group was higher than that of the control group (P ＜ 0.05). There was no statistical significance in intraocular pressure between the two groups (P ＞ 0.05). Six months after treatment, there was a significant difference in clinical effects between the two groups (P ＜ 0.05). There were no statistically significant differences in plasma viscosity (PV), erythrocyte aggregation index (EAI), erythrocyte deformation index (EDI), erythrocyte sedimentation rate (ESR), and hematocrit (Hct) between the two groups before treatment (P ＞ 0.05); six months after treatment, PV, EAI, EDI, ESR, and Hct in both groups were decreased (P ＜ 0.05), and which in the observation group were lower than those in the control group (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (P ＞ 0.05). Conclusion The treatment of DR patients with conbercept injection combined with 532 nm laser panretinal photocoagulation can reduce CMT, improve vision, and has a definite effect, and it can improve the fundus microcirculation.
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