Research progress of miR-135a / FOXO1 / PINK1 regulatory axis in liver fibrosis and mitochondrial autophagy#br#
PANG Qiulin1 WANG Zhenchang2
1.Graduate School, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530000, China;
2.Department of Spleen, Stomach and Liver Diseases, Guangxi International Zhuang Medical Hospital, Guangxi Zhuang Autonomous Region, Nanning 530000, China
Abstract：Hepatic fibrosis is a common pathological stage of all chronic liver diseases and a necessary process for the development of liver cirrhosis. Its causes are complex, lack of effective treatments, and its incidence is increasing year by year, it is a reversible damage-repair process. Therefore, how to block and reverse liver fibrosis is the key to treatment. Autophagy is closely related to liver fibrosis, and the role of mitochondrial autophagy in liver fibrosis has received increasing attention from many researchers. This article discusses the regulatory relationship between liver fibrosis and the miR-135a / FOXO1 / PINK1 regulatory axis of mitochondrial autophagy, and aims to provide scientific reference and new ideas for the treatment of liver fibrosis and the research of new anti-liver fibrosis drugs.
[1] Weiskirchen R. Special Issue on “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” [J]. Cells，2020，9（5）：1105.
[2] Rita R，Caterina F. Liver，Oxidative Stress and Metabolic Syndromes [J]. Nutrients，2021，13（2）：301.
[3] Nabil E，Yuko I，Yoshinori O. Triggering of Parkin Mitochondrial Translocation in Mitophagy：Implications for Liver Diseases [J]. Front Pharmacol，2016，7（18）：1-6.
[4] Elena O，Rosario S，Rafael L，et al. The Link between Oxidative Stress，Redox Status，Bioenergetics and Mitochondria in the Pathophysiology of ALS [J]. Int J Mol Sci，2021， 22（12）：6352.
[5] Wang Y，Han Z，Xu Z，et al. Protective Effect of Optic Atrophy 1 on Cardiomyocyte Oxidative Stress： Roles of Mitop-hagy，Mitochondrial Fission，and MAPK/ERK Signaling [J]. Oxid Med Cell Longev，2021，2021：3726885.
[6] Ayd?覦n MM，Ak?觭al?覦 KC. Liver fibrosis [J]. Turk J Gastroenterol，2018，29（1）：14-21.
[7] Xu Y，Sun X，Zhang R，et al. A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis [J]. Cell Reports，2020，30（5）：1310-1318.
[8] Hur W，Kang BY，Kim SM，et al. Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells [J]. Cells，2019，8（10）：1119.
[9] Rizwan H，Pal S，Sabnam S，et al. High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes [J]. Life Sci，2020，241：117148.
[10] Xiao X，Yuan Q，Chen Y，et al. LncRNA ENST00000453774.1 contributes to oxidative stress defense dependent on autophagy mediation to reduce extracellular matrix and alleviate renal fibrosis [J]. J Cell Physiol，2019，234（6）：9130-9143.
[11] Ruart M，Chavarria L，Campreciós G，et al. Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury [J]. J Hepatol，2019，70（3）：458-469.
[12] Li H. Angiogenesis in the progression from liver fibrosis to cirrhosis and hepatocelluar carcinoma [J]. Expert Rev Gastroenterol Hepatol，2021，15（3）：217-233.
[13] Gan D，Zhang W，Huang C，et al. Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway [J]. J Cell Physiol，2018，233（10）：6799-6813.
[14] Theerut L，Su S，Mut H，et al. Targeting Oxidative Stress for the Treatment of Liver Fibrosis [J]. Rev Physiol Biochem Pharmacol，2018，175：71-102.
[15] Huda N，Zou H，Yan S，et al. Analysis of Autophagy for Liver Pathogenesis [J]. Methods Mol Biol，2019，1880：481-489.
[16] Hu T，Sun H，Deng WY，et al. Augmenter of Liver Regeneration Protects Against Acetaminophen-Induced Acute Liver Injury in Mice by Promoting Autophagy [J]. Shock，2019，52（2）：274-283.
[17] An P，Wei LL，Zhao S，et al. Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis [J]. Nat Commun，2020，11（1）：2362.
[18] Ding Q，Xie XL，Wang MM，et al. The role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis [J]. Exp Mol Med，2019，51（1）：1-13.
[19] Huang J，Zhu T，Rong R，et al. FUN14 domain-containing 1-mediated mitophagy suppresses interleukin-1β production in macrophages [J]. Int Immunopharmacol，2020，88：106964.
[20] Qiu YN，Wang GH，Zhou F，et al. PM2.5 induces liver fibrosis via triggering ROS-mediated mitophagy[J]. Ecotoxicol Environ Saf，2019，167：178-187.
[21] Xing YQ，Li A，Yang Y，et al. The regulation of FOXO1 and its role in disease progression [J]. Life Sci，2018， 193：124-131.
[22] Wei R，Cao J，Yao S. Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways [J]. Cell Stress Chaperones，2018，23（6）：1295-1309.
[23] Huang XY，Li D，Chen ZX，et al. Hepatitis B Virus X protein elevates Parkin-mediated mitophagy through Lon Peptidase in starvation [J]. Exp Cell Res，2018，368（1）：75-83.
[24] Sato S，Furuya N. Induction of PINK1/Parkin-Mediated Mitophagy [J]. Methods Mol Biol，2018，1759：9-17.
[25] Cheng Z. The FoxO-Autophagy Axis in Health and Disease [J]. Trends Endocrinol Metab，2019，30（9）：658-671.
[26] Shi HZ，Wang DN，Xu F，et al. miR-135a inhibits glioma cell proliferation and invasion by directly targeting FOXO1 [J]. Eur Rev Med Pharmacol Sci，2018，22（13）：4215-4223.
[27] von Stockum S，Marchesan E，Ziviani E. Mitochondrial quality control beyond PINK1/Parkin [J]. Oncotarget，2018，9（16）：12550-12551.
[28] Wen L，Du M，Wang Q，et al. FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway [J]. Endocrinology，2017，158（7）：2155-2167.
[29] Imai Y. PINK1-Parkin signaling in Parkinson’s disease：Lessons from Drosophila [J]. Neurosci Res，2020，159：40-46.
[30] Bowling JL，Skolfield MC，Riley WA，et al. Temporal integration of mitochondrial stress signals by the PINK1：Parkin pathway [J]. BMC Mol Cell Biol，2019，20（1）：33.
[31] Wang Z，Han S，Chen X，et al. Eva1a inhibits NLRP3 activation to reduce liver ischemia-reperfusion injury via inducing autophagy in kupffer cells [J]. Mol Immunol，2021，132：82-92.
[32] Willson J. Mitosis flips the switch on autophagy contro [J]. Nat Rev Mol Cell Biol，2020，21（1）：4-5.
[33] Xu F，Hua C，Tautenhahn HM，et al. The Role of Autophagy for the Regeneration of the Aging Liver [J]. Int J Mol Sci，2020，21（10）：3606.
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