Research progress of neural stem cell transplantation for neuroprotective and regenerative therapy of ischemic stroke#br#
SHEN Youjin1 QI Xiaokun2 ZHOU Zonghua1 HE Jianwen1
1.Department of Neurology, Deqing County People’s Hospital of Zhaoqing Ctiy, Guangdong Province, Zhaoqing 526600, China;
2.Department of Neurology, the Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China
Abstract：Ischemic stroke is a disease with high incidence and disability rate. Intravenous thrombolysis and mechanical thrombectomy are two most effective therapies for acute ischemic stroke. However, due to the limitations of therapy time window and surgical techniques, there are many patients who cannot fully or largely recover after the treatment of ischemic stroke. Neural stem cell transplantation provides a new method for the treatment of ischemic stroke. By promoting neurogenesis, angiogenesis, synaptic remodeling, cell replacement, and other mechanisms, neural stem cells play a good effect in the treatment of ischemic stroke. Although there are some problems such as insufficient source of neural stem cell, the optimal transplantation dose and route of administration, unclear time window, and tumorigenicity, neural stem cell transplantation is still a promising therapeutic method.
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