心肌梗死后心肌再生相关调节机制的研究进展

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摘要心肌梗死后组织缺血缺氧，梗死区域大量心肌细胞坏死，受损的组织被纤维化细胞代替，形成瘢痕组织，非梗死区的心室壁重塑，导致心肌收缩能力下降，最终造成心力衰竭。根据世界卫生组织的最新报告，心肌梗死和其他心血管疾病是全球主要的致死疾病。近些年心肌梗死发病患者年轻化的问题日益凸显，总体死亡率呈上升趋势。心肌再生是心肌梗死后，原有的心肌细胞少量增殖，缓解心肌梗死造成损伤的过程。研究表明，可以通过促进心肌细胞的自我复制促使心肌梗死后的心肌再生。本文对目前心肌梗死的内源性修复研究进展进行总结，探讨microRNA、细胞因子通过一些特定的信号通路，诱导心肌细胞重新进入细胞周期，实现心肌细胞的增殖。对目前现有的心肌再生相关调节机制进行综述，以期寻找到治疗心肌梗死的新思路。

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	马逸夫1
	2 刘婷婷1
	2 孙芳玲1
	2 田欣1
	2 王宇峰1
	2 郑瑞芳3 邢建国3 王文1
	2
	3
	4▲

关键词 ：心肌梗死, 心肌再生, microRNA, 信号通路, 细胞因子

Abstract：After myocardial infarction, the tissue is ischemic and hypoxic, and a large number of myocardial cells in the infarction area are necrotic, and the damaged tissue is replaced by fibrotic cells, forming scar tissue. Remodeling of the ventricular wall in the non-infarcted area leads to a decrease in the ability of the heart muscle to contract, ultimately leading to heart failure. According to the latest report of the World Health Organization, myocardial infarction and other cardiovascular diseases are the leading causes of death worldwide. In recent years, the problem of younger patients with myocardial infarction has become increasingly prominent, and the overall mortality is on the rise. Myocardial regeneration is a process in which the original myocardial cells proliferate a little after myocardial infarction to alleviate the injury caused by myocardial infarction. Studies have shown that myocardial regeneration after myocardial infarction can be promoted by promoting the self-replication of myocardial cells. In this paper, the current research progress on endogenous repair of myocardial infarction is summarized, and microRNA and cytokines are discussed to induce myocardial cells to re-enter the cell cycle and realize the proliferation of myocardial cells through some specific signaling pathways. In order to find a new way to treat myocardial infarction, this paper reviews the existing regulation mechanism of myocardial regeneration.

Key words： Myocardial infarction Myocardial regeneration microRNA Signal pathway Cytokines

基金资助:国家自然科学基金资助项目（81503049、815736 33）；
新疆维吾尔自治区层次人才引进工程天池计划（柔性引进人才）项目。

通讯作者: ▲通讯作者

作者简介: 马逸夫（1997-），男，首都医科大学宣武医院2020级药理学专业在读硕士研究生；研究方向：心血管药理学。

引用本文:

马逸夫1,2 刘婷婷1,2 孙芳玲1,2 田欣1,2 王宇峰1,2 郑瑞芳3 邢建国3 王文1,2,3,4▲ . 心肌梗死后心肌再生相关调节机制的研究进展[J]. 中国医药导报, 2021, 18(36): 40-44.
MA Yifu1,2 LIU Tingting1,2 SUN Fangling1,2 TIAN Xin1,2 WANG Yufeng1,2 ZHENG Ruifang3 XING Jianguo3 WANG Wen1,2,3,4▲. Research progress on the regulatory mechanism of myocardial regeneration after myocardial infarction#br#. 中国医药导报, 2021, 18(36): 40-44.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I36/40

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