Abstract：Objective To study antibacterial effect of Shuanghuanglian combined with minocycline and Piperacillin /Taz-obactam and Cefoperazone / Sulbactam on extensively drug-resistant Acinetobacter baumannii in vitro. Methods A total of 30 strains extensively drug-resistant Acinetobacter baumannii were collected from clinical specimens from October 2016 to June 2017 in Beijing University of Chinese Medicine Third Affiliated Hospital. The minimum inhibitory concentration (MIC) of Shuanghuanglian and minocycline, Piperacillin / Tazobactam, Cefoperazone / Sulbactam (Cefoperazone / Sulbactam) in 30 strains extensively drug-resistant Acinetobacter baumannii was tested by the broth dilution method, and the partial inhibitory concentration (FIC) index was calculated, and the combined bacteriostasis effect of Chinese and Western medicine was determined. Results The FIC index of Shuanghuanglian combined with minocycline: 0.5-1 accounted for 6.7%, >1-2 accounted for 63.3%, and >2 accounted for 30.0%; the FIC index of Shuanghuanglian combined with Piperacillin / Tazobactam: 0.5-1 accounted for 16.7%, >1-2 accounted for 83.3%; the FIC index of Shuanghuanglian combined with Cefoperazone / Sulbactam: ≤ 0.5 accounted for 23.3%, 0.5-1 accounted for 73.3%, >1-2 accounted for 3.3%. Conclusion Shuanghuanglian combined with minocycline and Piperacillin / Tazobactam has a non-independent and antagonistic effect on the extensively drug-resistant Acinetobacter baumannii, and the combined antibacterial effect in vitro is poor. The combined antibacterial effect of Shuanghuanglian combined with Cefoperazone / Sulbactam is better.
2018, Vol. 15 
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