Clinical analysis of anti-CASPR2 antibody associated autoimmune encephalitis#br#
JI Peng1 KOU Qixing1 SUN Gen1 QU Xueping1 JIANG Limin2▲
1.Department of Neurology, the Third People’s Hospital of Zhengzhou Tumor Hospital of Henan University, Henan Province, Zhengzhou 450000, China; 2.Department of Physical Examination, the First Affiliated Hospital of Henan University of Chinese Medicine, Henan Province, Zhengzhou 450000, China
Abstract：Objective To investigate the clinical features and treatment of anti-contactin associated protein-like 2(CASPR2) antibody associated autoimmune encephalitis. Methods Clinical data of five cases of anti-CASPR2 antibody associated autoimmune encephalitis diagnosed in the Third People’s Hospital of Zhengzhou and the First Affiliated Hospital of Henan University of Chinese Medicine from March 2017 to December 2020 were retrospectively analyzed. Results Among the five patients, there were three male patients, one patient had a history of fever before onset, two patients showed abnormal mental behavior, two patients showed epilepsy as the first symptom, and one patient showed memory loss. One patient had insomnia based on nerve pain, one patient had insomnia combined with cerebellar symptoms, and two patient had autonomic nerve dysfunction. Serum anti-CASPR2 antibody was positive in five patients, and cerebrospinal fluid anti-CASPR2 antibody was positive in one patient. All patients received immunotherapy, and the treatment was effective. Conclusion Anti-CASPR2 antibody associated autoimmune encephalitis may involve the central nervous system, the peripheral nervous system, the autonomic nervous system and other systems, leading to variable clinical syndrome, and immunotherapy is effective.
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