Detection of CRP and Lp(a) levels and correlation with myocardial injury during PCI perioperative period in patients with coronary heart disease and angina pectoris #br#
ZHAN Yongzhong1 XU Xianbin1 HUANG Zewei2
1.Department of Cardiology, Chaozhou Central Hospital, Guangdong Province, Chaozhou 521000, China;
2.Department of Laboratory, Chaozhou Central Hospital, Guangdong Province, Chaozhou 521000, China
Abstract：Objective To observe the levels of C-reactive protein (CRP) and lipoprotein (a) [Lp(a)] in the percutaneous coronary intervention (PCI) perioperative period in patients with coronary heart disease and angina pectoris and their correlation with myocardial injury. Methods The clinical data of 80 patients with coronary heart disease and angina pectoris diagnosed and treated in Chaozhou Central Hospital in Guangdong Province (“our hospital” for short) from March 2020 to March 2021 were retrospectively analyzed. According to the type of angina pectoris, they were divided into stable group (stable angina pectoris, 38 cases), and unstable group (unstable angina, 42 cases). In addition, 50 healthy people who received physical examination in our hospital during the same period were selected as the control group. The immunoscattering turbidimetric method was used to detect the CRP level, the cardiac marker detector was used to detect the cardiac troponin T (cTnT) level, and the Beckman DXC600 detector was used to detect the Lp(a) level. According to the postoperative value of cTnT, they were divided into normal group (cTnT＜0.014 μg/L, 32 cases) and elevated group (cTnT＞0.014 μg/L, 48 cases), and the levels of CRP and Lp(a) were compared between the two groups. At the same time, multivariate logistic regression was selected to analyze the correlation between CRP, Lp(a) levels and myocardial injury. Results The CRP and Lp(a) levels of the stable group and the unstable group were higher than those of the control group, while the unstable group was higher than the stable group, and the differences were statistically significant (P ＜ 0.05). The levels of CRP and Lp(a) in the elevated group were higher than those in the normal group, and the differences were statistically significant (P ＜ 0.05). High levels of CRP and Lp(a) were independent risk factors for the increase of cTnT in patients with coronary heart disease and angina pectoris during PCI perioperative period (OR ＞ 1, P ＜ 0.05). Conclusion The levels of CRP and Lp(a) in patients with coronary heart disease and angina pectoris increased significantly during PCI perioperative period, and the increased levels of CRP and Lp(a) are independent risk factors for myocardial injury after PCI.
詹永忠1 许贤彬1 黄泽伟2. 冠心病心绞痛患者PCI围手术期CRP、Lp（a）水平检测及其与心肌损伤的相关性[J]. 中国医药导报, 2021, 18(35): 76-79.
ZHAN Yongzhong1 XU Xianbin1 HUANG Zewei2. Detection of CRP and Lp(a) levels and correlation with myocardial injury during PCI perioperative period in patients with coronary heart disease and angina pectoris #br#. 中国医药导报, 2021, 18(35): 76-79.
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