Abstract：Cervical cancer is the most common malignant tumor of female reproductive system, middle and advanced stage and postoperative high-risk factors of early cervical cancer need supplementary treatment, mainly radiotherapy. Improving the sensitivity of cervical cancer to radiation has always been an urgent problem for gynecological oncologists. Recent studies have found that radioresistance of cervical cancer is closely related to cancer stem cell, DNA damage repair, and tumor microenvironment. The mechanisms of radioresistance induced by cancer stem cell include epithelial-mesenchymal transformation, hypoxia, oxidative regulation, intracellular phagocytosis, and inflammatory reaction, etc. Factors related to DNA damage repair pathway, such as ataxic telangiectasia-mutant gene, ATM-Rad3-related protein kinase, and genes interacting with the pathway, may be targets for improving radiotherapy sensitivity. Some factors in tumor microenvironment play a role in radioresistance of cervical cancer. The above factors are interrelated and interact with each other, and their specific mechanism of action affects the sensitivity and efficacy of radiotherapy for cervical cancer. This paper reviews the research progress on the mechanism of radioresistance of cervical cancer.
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