Clinical efficacy of modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b in the treatment of chronic hepatitis B and its influence on liver function and liver fibrosis#br#
HUANG Dawei1 LU Dingbo1 JIANG Shiyi1 LI Hanmin2
1.Department of Liver Disease, Hubei Hospital of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China;
2.Li Hanmin’s Old Traditional Chinese Medicine Inheritance Studio, Hubei Institute of Traditional Chinese Medicine and Liver Disease, Hubei Province, Wuhan 430074, China
Abstract：Objective To explore the clinical efficacy of modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b in the treatment of chronic hepatitis B (CHB) and its influence on liver function and liver fibrosis. Methods A total of 70 CHB patients in Hubei Hospital of Traditional Chinese Medicine from September 2017 to December 2019 were divided into the observation group（35 cases） and the control group（35 cases）by random number table method, the control group was treated with pegylated interferon α-2b, and the observation group was treated with modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b, the traditional Chinese medicine symptom score, liver function index (serum total bilirubin [TBil], alanine aminotransferase [ALT], asparagine aminotransferase [AST], serum albumin [ALB]), liver fibrosis index (type Ⅲ procollagen [PCⅢ], collagen typeⅣ[Ⅳ-C], layer mucins [LN], hyaluronidase [HA]), HBV markers (ALT normalization rate, hepatitis B virus [HBV]-DNA negative conversion rate and Hepatitis B E antigen [HbeAg] negative conversion rate) before and after treatment and adverse reactions were compared between the two groups. Results Before treatment, there were no significant differences in traditional Chinese medicine symptom scores between the two groups (P ＞ 0.05); after treatment, traditional Chinese medicine symptom scores of the two groups were lower than before treatment, and the observation group was lower than the control group (P ＜ 0.05). Before treatment, there were no significant differences in liver function indexes (TBil, ALT, AST, ALB) between two groups (P ＞ 0.05); after treatment, the ALB levels of the two groups were higher than those before treatment, while the TBil, ALT, AST levels were lower than before treatment, and the ALB levels of the observation group were higher than the control group, while the TBil, ALT, and AST levels were lower than the control group (P ＜ 0.05). Before treatment, there was no significant difference in liver fibrosis indexes (PCⅢ, Ⅳ-C, LN, and HA) between the two groups (P ＞ 0.05). After treatment, the levels of PCⅢ, Ⅳ-C, LN, and HA in the two groups were lower than those before treatment, and the observation group was lower than the control group (P ＜ 0.05). After six month follow-up, the HBeAg negative conversion rate of the observation group was significantly higher than those of the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P ＞ 0.05). Conclusion Modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b in the treatment of CHB is helpful to improve liver function and liver fibrosis. It has significant curative effect and good safety, and is worthy of clinical application.
黄大伟1 陆定波1 江诗怡1 李瀚旻2. 补肾生髓成肝方加减联合聚乙二醇干扰素α-2b治疗慢性乙型肝炎的效果及对患者肝功能及肝纤维化的影响[J]. 中国医药导报, 2021, 18(34): 86-90.
HUANG Dawei1 LU Dingbo1 JIANG Shiyi1 LI Hanmin2. Clinical efficacy of modified Bushen Shengsui Chenggan Preparation combined with pegylated interferon α-2b in the treatment of chronic hepatitis B and its influence on liver function and liver fibrosis#br#. 中国医药导报, 2021, 18(34): 86-90.
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