基于纤维化的窦房结功能不全与心房颤动发病机制的研究进展

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摘要窦房结功能不全和心房颤动都是临床上常见的心律失常，二者经常共存并相互作用。心脏纤维化是一系列病理状况的标志，也是导致患者心脏功能障碍和预后不良的危险因素。目前许多研究表明纤维化与窦房结功能不全和心房颤动的发生发展密切相关，本文从纤维化在窦房结功能不全与心房颤动中的发病机制及其影响因素进行综述，从而了解窦房结疾病和心房颤动之间的复杂关系，为临床上治疗窦房结功能不全及心房颤动提供新的思路。

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	张一丹1 王贺2 司春婴2 曹英杰3 解金红2

关键词 ：窦房结功能不全, 心房颤动, 纤维化

Abstract：Sinoatrial node dysfunction and atrial fibrillation are common arrhythmias in clinic, and they often coexist and interact with each other. Cardiac fibrosis is a marker of a series of pathological conditions and a risk factor leading to cardiac dysfunction and poor prognosis. At present, many studies have shown that fibrosis is closely related to the occurrence and development of sinoatrial node dysfunction and atrial fibrillation. This paper reviews the pathogenesis and influencing factors of fibrosis in sinoatrial node dysfunction and atrial fibrillation, to understand the complex relationship between sinoatrial node disease and atrial fibrillation, and to provide new ideas for clinical treatment of sinoatrial node dysfunction and atrial fibrillation.

Key words： Sinoatrial node dysfunction Atrial fibrillation Fibrosis

基金资助:国家自然科学基金资助项目（81473508、816034 31）。

通讯作者: 解金红（1969.12-），男，教授，硕士生导师，主任医师，河南中医院大学第一附属医院心脏中心主任；研究方向：心律失常的研究及治疗。

作者简介: 张一丹（1994.9-），女，河南中医药大学2018级内科学专业在读硕士研究生；研究方向：心电生理基础与临床。

引用本文:

张一丹1 王贺2 司春婴2 曹英杰3 解金红2. 基于纤维化的窦房结功能不全与心房颤动发病机制的研究进展[J]. 中国医药导报, 2021, 18(34): 43-46.
ZHANG Yidan1 WANG He2 SI Chunying2 CAO Yingjie3 XIE Jinhong2. Research progress on pathogenesis of sinoatrial node dysfunction and atrial fibrillation based on fibrosis#br#. 中国医药导报, 2021, 18(34): 43-46.

链接本文:

https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I34/43

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