Clinical effect of modified Linggui Zhugan Decoction combined with Metformin in the treatment of obesity type 2 diabetes mellitus with phlegm-dampness syndrome#br#
LUO Li1 LIU Chungu1 HUANG Yu2 ZHANG Zhenyu2 YU Yaohe1 LONG Shuni1
1.Department of Traditional Chinese Medicine, Guangzhou Xinhai Hospital, Guangdong Province, Guangzhou 510300, China;
2.Department of Endocrinology, Guangzhou Xinhai Hospital, Guangdong Province, Guangzhou 510300, China
Abstract：Objective To observe the clinical effect of modified Linggui Zhugan Decoction combined with Metformin in the treatment of obesity type 2 diabetes mellitus (T2DM) with phlegm-dampness syndrome. Methods Seventy obesity T2DM patients with phlegm-dampness syndrome in Guangzhou Xinhai Hospital from February 2018 to May 2021 were selected and divided into control group and experimental group by random number table method, with 35 cases in each group. All patients were treated with health education and lifestyle intervention. The control group were treated with Metformin, and the experimental group were treated with modified Linggui Zhugan Decoction combined with Metformin. Both groups were treated for six weeks. The changes of body mass index (BMI), waist-to-hip ratio (WHR), fasting blood glucose (FPG), 2 hours postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in two groups were compared before and after treatment, and the clinical efficacy of the two groups was evaluated. Results After treatment, BMI, WHR, FPG, 2hPG, HbA1c, TG, and LDL-C in two groups were lower than before treatment, and FPG, 2hPG, HbA1c, TG, and LDL-C in the experimental group were lower than those in the control group (P ＜ 0.05). After treatment, the clinical effect of the experimental group was better than the control group (P ＜ 0.05). Conclusion The clinical efficacy of modified Linggui Zhugan Decoction combined with Metformin in the treatment of obesity T2DM patients with phlegm-dampness syndrome is superior to that of Metformin alone, and it has advantages in regulating glucolipid metabolism disorder, which is worthy of clinical promotion.
罗力1 刘春菇1 黄钰2 张震宇2 余耀和1 龙舒妮1. 加味苓桂术甘汤联合二甲双胍治疗痰湿内盛证肥胖型2型糖尿病的临床效果[J]. 中国医药导报, 2021, 18(33): 127-130.
LUO Li1 LIU Chungu1 HUANG Yu2 ZHANG Zhenyu2 YU Yaohe1 LONG Shuni1. Clinical effect of modified Linggui Zhugan Decoction combined with Metformin in the treatment of obesity type 2 diabetes mellitus with phlegm-dampness syndrome#br#. 中国医药导报, 2021, 18(33): 127-130.
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