高纯度尿促性素对不同年龄卵巢储备功能减退患者体外受精的影响
赵海君1 卢静1 张一娇1▲ 王玉红1 陈静1 景丽1 常月婷2 张洪峰3
1.河北省邯郸市中心医院生殖医学科，河北邯郸 056000；
Effect of highly purified human menopausal gonadotrophin on in vitro fertilization in patients with diminished ovarian reserve at different ages#br#
ZHAO Haijun1 LU Jing1 ZHANG Yijiao1▲ WANG Yuhong1 CHEN Jing1 JING Li1 CHANG Yueting2 ZHANG Hongfeng3
1.Department of Reproductive Medicine, Handan Central Hospital, Hebei Province, Handan 056000, China;
摘要 目的 探讨高纯度尿促性素（HP-hMG）对卵巢储备功能减退（DOR）患者体外受精-胚胎移植的影响。 方法 选取2015年7月至2019年12月河北省邯郸市中心医院133例DOR患者，根据治疗方案将其分为重组促卵泡素组（A组，67例）和HP-hMG组（B组，66例）；将两组根据年龄（<35岁或≥35岁）继续分组，比较不同年龄下两组卵巢反应和妊娠结局。 结果 <35岁患者：B组促性腺激素（Gn）用量多于A组，扳机日雌激素（E2）水平低于A组，差异有统计学意义（P < 0.05）。两组累积妊娠率、累积活产率比较，差异无统计学意义（P > 0.05）。≥35岁患者：B组Gn用量、优质胚胎率高于A组，扳机日E2水平、获卵数低于A组，差异有统计学意义（P < 0.05）。两组累积妊娠率、累积活产率比较，差异无统计学意义（P > 0.05）。 结论 HP-hMG可明显提高≥35岁DOR患者的优质胚胎率。
关键词 ：
高纯度尿促性素 ,
卵巢储备功能减退 ,
超促排卵 ,
优质胚胎
Abstract ：Objective To investigate the effect of highly purified human menopausal gonadotropin (HP-hMG) on in vitro fertilization-embryo transfer in patients with diminished ovarian reserve (DOR) at different ages. Methods A total of 133 DOR patients from Handan Central Hospital of Hebei Province from July 2015 to December 2019 were selected, and they were divided into recombinant follicle stimulating hormone group (group A, 67 cases) and HP-hMG group (group B, 66 cases) according to treatment regimen; the two groups were further divided according to age (<35 years or ≥35 years), the ovarian response and pregnancy outcomes of the two groups at different ages were compared. Results Patients aged <35 years old: the amount of gonadotropin (Gn) in group B was higher than that in group A, and estrogen (E2) level on trigger day was lower than that in group A, with statistical significances (P < 0.05). There were no significant differences in cumulative pregnancy rate and cumulative live birth rate between two groups (P > 0.05). Patients aged ≥35 year old: the amount of Gn and top quality embryo rate in group B were higher than those in group A, E2 level on trigger day and egg number obtained were lower than those in group A, with statistical significances (P < 0.05). There were no significant differences in cumulative pregnancy rate and cumulative live birth rate between two groups (P > 0.05). Conclusion HP-hMG can significantly improve top quality embryo rate of DOR patients ≥35 years old.
Key words ：
Highly purified human menopausal gonadotrophin
Diminished ovarian reserve
Controlled ovarian stimulation
Top quality embryo
基金资助: 河北省健康医疗与生物医药专项(182777197)；
通讯作者:
▲通讯作者
作者简介 : 赵海君（1985.10-），女，硕士；研究方向：辅助生殖技术。
引用本文:
赵海君1 卢静1 张一娇1▲ 王玉红1 陈静1 景丽1 常月婷2 张洪峰3. 高纯度尿促性素对不同年龄卵巢储备功能减退患者体外受精的影响[J]. 中国医药导报, 2021, 18(33): 111-114.
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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I33/111
[1] Ata B，Seyhan A，Seli E. Diminished ovarian reserve versus ovarian aging：overlaps and differences [J]. Curr Opin Obstet Gynecol，2019，31（3）：139-147.
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