Abstract：Objective To investigate the characteristics of multiple infection of human papillomavirus (HPV) and its relationship with cervical lesions, which can provide references for the screening, treatment and vaccine development of cervical diseases. Methods The clinical data of 1175 patients with cervical pathology in the First Affiliated Hospital of Guangzhou Medical University from January 2014 to January 2020 were retrospectively analyzed. According to the different pathological diagnosis, they were divided into cervicitis group (107 cases), cervical intraepithelial neoplasia (CIN)Ⅰ group (364 cases), CIN Ⅱ-Ⅲ group (447 cases) and cervical cancer group (257 cases). The number of multiple infection of HPV cases, age distribution characteristics, infection type, and characteristics form of patients with different pathological types were compared. Results There were 291 cases of multiple infection of HPV, and the multiple infection rate was 24.77%. There were statistical differences in the incidence of multiple infection among different pathological types (P < 0.05). CIN Ⅰ was the predominant type of multiple infection of HPV in people under 30 years old, and CIN Ⅱ-Ⅲ was the predominant multiple infection of HPV in people after 30 years old. The highest HPV type detection rate of the first three kinds of subtypes were high-risk, respectively, HPV16, 52 and 58. Different cervical lesions were dominated by high-risk HPV mixed with other types of infection, and the proportion of double infection was the highest. Conclusion Multiple infection of HPV are found to be associated with the progression of cervical intraepithelial neoplasia, the prevention and treatment should be focused on patients under 30 years of age and patients with multiple HPV infections of HPV16, 52 and 58.
王梓慈 陈晓静 陈金娇 范良生 王薇 肖海群. 人乳头瘤病毒多重感染特点及其与宫颈病变的关系[J]. 中国医药导报, 2021, 18(33): 99-101,106.
WANG Zici CHEN Xiaojing CHEN Jinjiao FAN Liangsheng WANG Wei XIAO Haiqun . Characteristics of multiple infection of human papillomavirus and its relationship with cervical lesions#br#. 中国医药导报, 2021, 18(33): 99-101,106.
[1] Cohen PA，Jhingran A，Oaknin A，et al. Cervical cancer [J]. Lancet，2019，393（10167）：169-182.
[2] Wang Q，Qin Q，Song R，et al. NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression [J]. Cell Death Dis，2018，9（6）：668.
[3] Mirabello L，Yeager M，Yu K，et al. HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis [J]. Cell，2017，170（6）：1164-1174.
[4] 马莉，丛笑，卞美璐，等.高危型HPV分型检测作为子宫颈癌及其癌前病变初筛手段的探讨[J].中华妇产科杂志，2015，50（4）：246-252.
[5] 陈静娴，杨敏，何迅，等.2014—2018年成都市某医院13798例就诊女性HPV感染情况与基因亚型分析[J].现代预防医学，2021，48（3）：542-545.
[6] Gallegos-Bola?觡os J，Rivera-Domínguez JA，Presno-Bernal JM，et al. High prevalence of co-infection between human papillomavirus（HPV）51 and 52 in Mexican population [J]. BMC Cancer，2017，17（1）：531.
[7] 单玮，张涛，张铁军，等.我国女性人乳头瘤病毒（HPV）感染的流行病学现状[J].中华疾病控制杂志，2017，21（1）：89-93.
[8] Koeneman MM，Kruitwagen RF，Nijman HW，et al. Natural history of high-grade cervical intraepithelial neoplasia：a review of prognostic biomarkers [J]. Expert Rev Mol Diagn，2015，15（4）：527-546.
[9] Chen W，Zheng R，Baade PD，et al. Cancer statistics in China，2015[J]. CA Cancer J Clin，2016，66（2）：115-132.
[10] Bray F，Ferlay J，Soerjomataram I，et al. Global cancer statistics 2018：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin，2018，68（6）：394-424.
[11] Onuki M，Matsumoto K，Iwata T，et al. Human papillomavirus genotype contribution to cervical cancer and precancer：Implications for screening and vaccination in Japan [J]. Cancer Sci，2020，111（7）：2546-2557.
[12] 中华医学会妇科肿瘤学分会，中国优生科学协会阴道镜和宫颈病理学分会.人乳头瘤病毒疫苗临床应用中国专家共识[J].中国医学前沿杂志：电子版，2021，13（2）：1-12.
[13] 黄麦华，王中东，宗玉龙，等.5528例妇科患者高危型人乳头瘤病毒感染的基因分型、数量及年龄分布情况[J].中国妇幼保健，2020，35（13）：2402-2404.
[14] 黄春化，王碧霞，李华梅.HPV单一感染与多重感染对宫颈病变影响的临床分析[J].中国医药科学，2019，9（23）：136-138.
[15] 李洋，李永丽，王芦萍.HPV感染型别及多重感染对宫颈病变的影响[J].中华医院感染学杂志，2019，29（22）：3461-3464.
[16] 郭思洁，田黎黎，孔琪，等.武昌区域单中心人乳头瘤病毒感染及不同基因型的分布特征[J].中国实用妇科与产科杂志，2019，35（1）：123-126.
[17] Schmitt M，Depuydt C，Benoy I，et al. Multiple Human Papillomavirus Infections with High Viral Loads Are Associated with Cervical Lesions but Do Not Differentiate Grades of Cervical Abnormalities [J]. J Clin Microbiol，2013，51（5）：1458-1464.
[18] 陶萍萍，卞美璐，李敏，等.HPV多重感染与宫颈病变关系探讨[J].中国妇产科临床杂志，2006，7（2）：94-96，127.
[19] De Brot L，Pellegrini B，Moretti ST，et al. Infections with multiple high-risk HPV types are associated with high-grade and persistent low-grade intraepithelial lesions of the cervix [J]. Cancer Cytopathol，2017，125（2）：138-143.
[20] Oyervides-Mu?觡oz MA，Pérez-Maya AA，Sánchez-Domí-nguez CN，et al. Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women [J]. Viruses，2020，12（4）：380.
[21] Dickson EL，Vogel RI，Geller MA，et al. Cervical cytology and multiple type HPV infection：A study of 8182 women ages 31-65 [J]. Gynecol Oncol，2014，133（3）：405-408.
[22] Mu?觡oz N，Bosch FX，de Sanjosé S，et al. Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer [J]. N Engl J Med，2003，348（6）：518-527.
[23] Adcock R，Cuzick J，Hunt WC，et al. Role of HPV Genotype，Multiple Infections，and Viral Load on the Risk of High-Grade Cervical Neoplasia [J]. Cancer Epidemiol Biomarkers Prev，2019，28（11）：1816-1824.
[24] Crosbie EJ，Einstein MH，Franceschi S，et al. Human papillomavirus and cervical cancer [J]. Lancet，2013，382（9895）：889-899.
[25] 李琳，李坤.女性生殖道人乳头瘤病毒多重感染基因谱的研究[J].现代妇产科进展，2013，22（7）：578-580.
[26] Cao D，Zhang S，Zhang Q，et al. Prevalence of high-risk human papillomavirus infection among women in Shaanxi province of China：A hospital-based investigation [J]. J Med Virol，2017，89（7）：1281-1286.
[27] Biryukov J，Meyers C. Superinfection Exclusion between Two High-Risk Human Papillomavirus Types during a Coinfection [J]. J Virol，2018，92（8）：e1917-e1993.
京公网安备 11010502046598号