Abstract：Objective To study the effect of Osteoking combined with closed reduction and percutaneous locking plate fixation (CRPLPF) on postoperative healing of tibial fracture. Methods From January 2017 to March 2019, 144 patients with middle and lower tibial fracture surgery in the Second Affiliated Hospital of Hainan Medical College were selected as research objects. According to the random number table method, they were divided into the control group and the observation group, with 72 cases in each group. The control group was treated with CRPLPF, and the observation group was treated with Osteoking on the basis of the control group. The detumescence time, fracture begin healing time, fracture healing time, serum insulin-like growth factor-1 (IGF-1), fibroblast growth factor-2 (FGF-2), bone gla-protein (BGP), bone alkaline phosphatase (BALP) levels, and hemorheology indexes of the two groups were observed. Results The observation group included 71 cases, and the control group included 69 cases. The postoperative detumescence time, fracture begin healing time and fracture healing time of the observation group were lower than those of the control group (P < 0.05). At four weeks after operation, the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, and erythrocyte aggregation index of the two groups were lower than those immediately after operation, and the observation group was lower than the control group (P < 0.05). At four weeks after operation, the levels of IGF-1, FGF-2, BGP, and BALP in the two groups were higher than those immediately after operation, and the observation group was higher than the control group (P < 0.05). The excellent and good rate in the observation group was higher than that in the control group (P < 0.05). Conclusion Application of Osteoking after CRPLPF can promote fracture healing and functional recovery.
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