Abstract：Objective To study the correlation between different onset ages of type 2 diabetes mellitus and late onset hypogonadism in male (LOH). Methods A total of 120 male patients with type 2 diabetes mellitus who were hospitalized in Beijing Friendship Hospital, Capital Medical University from October 2018 to March 2020 were selected. According to the age of onset of type 2 diabetes mellitus, they were divided into early onset group (＜ 40 years old, 54 cases) and late onset group (≥40 years old, 66 cases). The differences of clinical indicators between the two groups were collected and analyzed, and the correlation between total testosterone and age-related metabolic indicators was analyzed by Pearson and Spearman correlation coefficients. Results The disease course of the early onset group was shorter than that of the late onset group, the proportion of family history of diabetes, the proportion of new diabetes, body mass index, systolic blood pressure, glycosylated hemoglobin, fasting blood glucose, and triglyceride (TG) were higher than those of the late onset group, and high density lipoprotein cholesterol (HDL-C), follicle stimulating hormone, luteinizing hormone, the proportion of LOH were lower than those of the late onset group, the differences were statistically significant (P ＜ 0.05). Serum total testosterone level was negatively correlated with body mass index, fasting blood glucose, and TG (r or rs ＜ 0, P ＜ 0.05), but positively correlated with HDL-C (rs ＞ 0, P ＜ 0.05). Conclusion The onset age and related indexes of type 2 diabetes mellitus patients were correlated with LOH.
赵蕾 袁明霞 李如强. 2型糖尿病的发病年龄与男性迟发性性腺功能减退症相关性分析[J]. 中国医药导报, 2021, 18(33): 86-89.
ZHAO Lei YUAN Mingxia LI Ruqiang. Correlation analysis between onset age of type 2 diabetes mellitus and late onset hypogonadism in male#br#. 中国医药导报, 2021, 18(33): 86-89.
[1] Ma RC，Chan JC. Type 2 diabetes in East Asians：similarities and differences with populations in Europe and the United States [J]. Ann N Y Acad Sci，2013，1281（1）：64-91.
[2] Lascar N，Brown J，Pattison H，et al. Type 2 diabetes in adolescents and young adults [J]. Lancet Diabetes Endocrinol，2018，6（1）：69-80.
[3] Al-Saeed AH，Constantino MI，Molyneaux L，et al. An inverse relationship between age of type 2 diabetes onset and complication risk and mortality：the impact of youth-onset type 2 diabetes [J]. Diabetes Care，2016，39（5）：823-829.
[4] Yeow TP，Hor CP，Lim SL，et al. Challenges in the classification and management of Asian youth-onset diabetes mellitus-lessons learned from a single centre studys [J]. PLoS One，2019，14（1）：e0211210.
[5] Alberti KG，Zimmet PZ. Definition，diagnosis and classification of diabetes mellitus and its complications. Part 1：diagnosis and classification of diabetes mellitus provisional report of a WHO consultation [J]. Diabet Med，1998，15（7）：539-553.
[6] Muntner P，Whelton PK，Woodward M，et al. A Comparison of the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline and the 2017 American Diabetes Association Diabetes and Hypertension Position Statement for U.S. Adults With Diabetes [J]. Diabetes Care，2018，41（11）：2322-2329.
[7] Wang C，Nieschlag E，Swerdloff R，et al. ISA，ISSAM，EAU，EAA and ASA recommendations：investigation，treatment and monitoring of late-onset hypogonadism in males [J]. Int J Impot Res，2009，21（1）：1-8.
[8] Yeung R，Zhang Y，Luk A，et al. Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia（the JADE programme）：a cross-sectional study of a prospective cohort [J]. Lancet Diabetes Endocrinol，2014，2（12）：935-943.
[9] 曾婷婷，严励.成人超重/肥胖合并糖尿病的综合管理[J].临床内科杂志，2020，37（9）：607-610.
[10] Kong X，Xing X，Zhang X，et al. Early-onset type 2 diabetes is associated with genetic variants of β-cell function in the Chinese Han population [J]. Diabetes Metab Res Rev，2020，36（2）：e3214.
[11] Li Y，Zhang M，Liu X，et al. Correlates and prevalence of hypogonadism in patients with early-and late-onset type 2 diabetes [J]. Andrology，2017，5（4）：739-743.
[12] 吉正国.男性更年期综合征的发病机制与诊断[J].中华全科医师杂志，2017，16（6）：421-423.
[13] 于骐玮，郭海彬.骨钙素与男性迟发性性腺功能减退症相关性的研究进展[J].中国医药科学，2020，10（7）：36-39.
[14] 陈康宁，刘星辰，高轲，等.中老年男性2型糖尿病患者合并迟发性性腺功能减退症的研究进展[J].中国男科学杂志，2018，32（3）：68-72.
[15] Corona G，Giorda CB，Cucinotta D，et al. The SUBITO-DE study：sexual dysfunction in newly diagnosed type 2 diabetes male patients [J]. J Endocrinol Invest，2013，36（10）：864-868.
[16] Corona G，Giorda CB，Cucinotta D，et al. Sexual dysfunction at the onset of type 2 diabetes：the interplay of depression，hormonal and cardiovascular factors [J]. J Sex Med，2014，11（8）：2065-2073.
[17] 梁国庆，李建辉，施慧娟.迟发性性腺功能减退症病人血清雄激素及其相关代谢指标水平差异分析[J].实用老年医学，2019，7（7）：701-705.
[18] 吴金华，王璐霞，郭树林，等.个体化睾酮替代疗法治疗男性迟发性性腺功能减退症患者对血清总睾酮和性激素水平的影响[J].中国现代医生，2019，57（23）：23-26.
[19] Maiuolo J，Gliozzi M，Musolino V，et al. The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier：Molecular Mechanisms and Pathophysiological Implications [J]. Int J Mol Sci，2019，20（12）：3022.
[20] Stellato RK，Feldman HA，Hamdy O，et al. Testosterone，sex hormone binding globulin and the development of Type 2 diabetes in middle aged men [J]. Diabetes Care，2000，23（4）：490-494.
[21] 袁虎，谢群，周建英，等.苏州地区健康青年男性血清总睾酮水平与代谢指标的相关性分析[J].中华男科学杂志，2019，25（12）：1139-1142.
[22] Permpongkosol S，Tantirangsee N，Ratana-olarn K. Treatment of 161 men with symptomatic late onset hypogonadism with long-acting parenteral testosterone undecanoate：effects on body composition，lipids，and psychosexual complaints [J]. J Sex Med，2010，7（11）：3765-3774.
[23] Corona G，Vignozzi L，Sfbrza A，et al. Obesity and late-onset hypogonadism [J]. Mol Cell Endocrinol，2015，15（418）：120-133.
[24] Ho HJ，Shirakawa H，Giriwono PE，et al. A novel function of geranylgeraniol in regulating testosterone production [J]. Biotech-nol Biochem，2018，82（6）：956-962.
[25] Ding B，Sun R，Zhai XF，et al. Association of high circulating testosterone with increased glycaemic variability in type 2 diabetes：A cross-sectional study in China [J]. Diabetes Metab Res Rev，2019，35（4）：e3126.
京公网安备 11010502046598号