Effect of moxibustion on wound repair in rats with pressure injuries
YU Jie1 SUN Zhongren2 LI Hongling3 ZHAO Hui2
1.Affiliated Hospital of Yangzhou University, Jiangsu Province, Yangzhou 225000, China;
2.Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
3.LI Hongling Surgical Clinic of Traditional Chinese Medicine, Heilongjiang Province, Harbin 150030, China
Abstract：Objective To observe the effect of moxibustion on wound repair in rats with pressure injuries. Methods The models of rats with pressure ulcers which belonged to stage 2-3 were established by using self-made devices of pressure ulcers. The models of 70 SD female rats with skin ischemia reperfusion injury were randomly divided into model group and moxibustion group. There were 35 rats in each group. Each group was divided into 5 subgroups including 1 d, 3 d, 5 d, 7 d and 10 d according to the length of intervention time. Seven experimental rats were included in each subgroup. The blank group was given shaving disinfection, tied together with other groups of rats given only conventional iodophor intervention. The model group was only given conventional iodophor intervention. The moxibustion group was given iodophor intervention at first and direct moxibustion intervention to the local tissue of pressure ulcer with cyclotron operation, with moxibustion once a day and 15 minutes each time. The wound area was measured respectively after five time-points (1 d, 3 d, 5 d, 7 d and 10 d after intervention or treatment) before drawing. HE staining was used to observe the pathological changes of the pressure ulcer. Results There were no significant differences in the wound healing rates between the groups in the 1 d after intervention(P > 0.05). Compared with the model group, the wound healing rates of moxibustion group were significantly higher at the four time-points including 3 d, 5 d, 7 d and 10 d after treatment. At the same time-points, there were significant differences between the two groups (P < 0.01). Compared with the model group, the granulation tissues in the wounds of rats which belonged to moxibustion group with pressure ulcers had obvious advantages both in the time-points and the growth states. There were granulation tissues at the third day after treatment in the moxibustion group, while those of model group appeared about at the seventh day after iodophor intervention. Simultaneously, the wound contraction rates of pressure ulcers were faster in the moxibustion group which had more evident area reductions. Pathological changes of pressure ulcers were observed by HE staining that the peaks of the inflammatory infiltrations which existed in the moxibustion group had appeared in advance compared with the model group. Meanwhile, fibroblasts appeared earlier, having more numbers and obvious degrees of hyperplasia. The occurrence time of granulation tissues was earlier in the moxibustion group. Hence, neovascularization which belonged to moxibustion group formed earlier than that of model group. The epidermal structures of rats in the moxibustion group recovered in advance. Conclusion Moxibustion can promote the wound healing effectively in rats with pressure injuries.
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2018, Vol. 15 
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