黄芪多糖与辛伐他汀对高脂血症大鼠治疗效果的动态对比研究

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摘要目的比较黄芪多糖和辛伐他汀对高脂血症大鼠的治疗效果。方法采用高脂饮食构建高脂血症大鼠模型。采用完全随机分组法将SD大鼠分为正常组、疾病模型组、辛伐他汀组和黄芪多糖组。正常组喂养基础饲料，其他三组喂养高脂饲料，其中黄芪多糖组以黄芪多糖按700 mg/kg灌胃，辛伐他汀组以辛伐他汀按6.7 mg/kg灌胃，正常组和疾病模型组灌胃生理盐水。记录大鼠饮水量、饮食量、摄能量、排泄量和体重，每4周采集1次血清标本，检测血糖、三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）含量的变化以及谷丙转氨酶（ALT）和谷草转氨酶（AST）活性变化。结果高脂饮食8周后，疾病模型组大鼠的摄能量、体重、血脂和转氨酶水平显著高于正常组（P ＜ 0.05），而饮食量、饮水量和排泄量则较正常组低（P ＜ 0.05）；药物干预4周后，辛伐他汀组大鼠TC、TG和LDL-C含量显著低于疾病模型组大鼠（P ＜ 0.05），黄芪多糖组和疾病模型组TC、TG和LDL-C含量差异无统计学意义（P ＞ 0.05）；药物干预8周后，黄芪多糖组和辛伐他汀组大鼠饮水量、排泄量、体重和血脂水平较疾病模型组大鼠明显改善（P ＜ 0.05）；此外，黄芪多糖组大鼠血糖、转氨酶水平较疾病模型组亦有明显改善作用（P ＜ 0.05），而辛伐他汀组对这些指标改善不明显。结论黄芪多糖降脂较慢，但延长给药时间也能达到同辛伐他汀一样的降脂效果，而且其对血糖和转氨酶的改善作用明显优于辛伐他汀。

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	袁前发唐思梦陈思羽杨泽民

关键词 ：黄芪多糖, 辛伐他汀, 高脂血症

Abstract：Objective To compare the therapeutic effects of astragalus polysaccharide and Simvastatin in rats with hyperlipidemia. Methods The model of rats with hyperlipidemia was induced by high fat diet. The SD rats were randomly divided into normal group, disease model group, Simvastatin group and astragalus polysaccharide group by completely random method. The normal group was fed with basal feed, the other three groups were fed with high fat diet, among which, the astragalus polysaccharide group was given astragalus polysaccharide 700 mg/kg by gavage, Simvastatin group was given Simvastatin 6.7 mg/kg by gavage, normal group and disease model group were given normal saline by gavage. The amount of water intake, food intake, energy intake, excretion and body weight of the rats were recorded. The serum samples were collected every 4 weeks. The changes of the contents of blood glucose, triacylglycerol (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected. Results After high fat diet for 8 weeks, the amount of energy intake, body weight and the levels of serum lipid, transaminase in disease model group were all significantly higher than those of normal group (P ＜ 0.05), while the amount of food intake, water intake, excretion were significantly lower than those of normal group (P ＜ 0.05). After drug intervention for 4 weeks, the contents of TC, TG and LDL-C in Simvastatin group were significantly lower than those of disease model group (P ＜ 0.05), while there were no statistically significant differences of the contents of TC, TG and LDL-C between astragalus polysaccharide group and disease model group (P ＞ 0.05). After drug intervention for 8 weeks, the amount of water intake, excretion, body weight and the levels of blood lipid in astragalus polysaccharide group and Simvastatin group were significantly improved compared with those of disease model group (P ＜ 0.05). In addition, the levels of blood glucose and transaminase in astragalus polysaccharide group were also significantly improved compared with those of disease model group (P ＜ 0.05), while the indexes above in the Simvastatin group were not significantly improved. Conclusion The effects of lipid-lowering of astragalus polysaccharide is slow, but it can achieve the same effects of lipid-lowering as Simvastatin through prolonging drug administration, and the improvement for blood glucose and transaminase is better than Simvastatin.

Key words： Astragalus polysaccharide Simvastatin Hyperlipidemia

基金资助:国家自然科学基金青年项目（81102703）；
广东省科学厅——省中医药科学院联合科研专项项目（2013A03 2500005）；
广东药科大学科技处——附属第一医院联合自然科学培育基金项目（GYFYLH201303）。

通讯作者: 杨泽民（1979-），男，博士，高级实验师；研究方向：中药药理学与临床应用。

作者简介: 袁前发（1991-），男，广东药科大学基础学院2015级病原生物学专业在读硕士研究生；研究方向：中药药理学与临床应用。

引用本文:

袁前发唐思梦陈思羽杨泽民. 黄芪多糖与辛伐他汀对高脂血症大鼠治疗效果的动态对比研究[J]. 中国医药导报, 2017, 14(23): 8-12.
YUAN Qianfa TANG Simeng CHEN Siyu YANG Zemin. Dynamic comparative study on the therapeutic effect of astragalus polysaccharide and Simvastatin in rats with hyperlipidemia. 中国医药导报, 2017, 14(23): 8-12.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I23/8

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