2型糖尿病伴非酒精性脂肪肝患者胱抑素C与胰岛素抵抗的相关性研究

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摘要目的探讨2型糖尿病（T2DM）伴非酒精性脂肪肝（NAFLD）患者胱抑素C与胰岛素抵抗的相关性。方法选择2013年10月～2015年10月在湛江中心人民医院内分泌科住院治疗的T2DM患者65例，根据肝脏彩超结果是否有NAFLD将患者分为T2DM伴NAFLD组（n=29）和T2DM组（n=36），分析两组患者的胱抑素C与胰岛素抵抗水平及两者的相关性。结果 T2DM伴NAFLD组胱抑素C和胰岛素抵抗指数水平高于T2DM组，差异有统计学意义（P ＜ 0.05）。T2DM伴NAFLD组胱抑素C与胰岛素抵抗的相关系数为0.79，而T2DM组胱抑素C与胰岛素抵抗的相关系数为0.43（P ＜ 0.05）。结论 T2DM伴NAFLD组胱抑素C与胰岛素抵抗呈正相关，且更易出现胰岛素抵抗。

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	莫小庆黄春宋青青陈文俊何宁宁

关键词 ： 2型糖尿病, 非酒精性脂肪肝, 胱抑素C, 胰岛素抵抗

Abstract：Objective To investigate the association between cystatin C and insulin resistance in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). Methods According to the results of ultrasonography detection of liver, 65 cases with T2DM in Central People′s Hospital of Zhanjiang from October 2013 to October 2015 were divided into two groups, including 29 cases of T2DM patients with NAFLD (T2DM+NAFLD group) and 36 cases of only T2DM (T2DM group). The levels of cystatin C and insulin resistance and correlation in both groups were analyzed. Results The levels of cystatin C and insulin resistance in T2DM+NAFLD group were higher than those in T2DM group, the differences were statistically significant (P ＜ 0.05). The correlation coefficient of cystatin C and insulin resistance in T2DM+NAFLD group was 0.79, while the correlation coefficient between cystatin C and insulin resistance in T2DM group was 0.43(P < 0.05). Conclusion Cystatin C and insulin resistance in T2DM with NAFLD group is positively correlated, and more prone to insulin resistance.

Key words： Type 2 diabetes mellitus Nonalcoholic fatty liver Cystatin C Insulin resistance

基金资助:广东省医学科学技术研究基金项目（B2013380）。

作者简介: 莫小庆（1985-），硕士；研究方向：糖尿病等内分泌代谢病。

引用本文:

莫小庆黄春宋青青陈文俊何宁宁. 2型糖尿病伴非酒精性脂肪肝患者胱抑素C与胰岛素抵抗的相关性研究[J]. 中国医药导报, 2017, 14(24): 78-80.
MO Xiaoqing HUANG Chun SONG Qingqing CHEN Wenjun HE Ningning. Correlation study of cystatin C and insulin resistance in type 2 diabetes mellitus patients with non-alcoholic fatty liver. 中国医药导报, 2017, 14(24): 78-80.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I24/78

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