1.Department of Vascular Gland Surgery, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Medical Department, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China
Abstract：In China, the incidence of CRC is reportedly increasing over time. The treatment options including surgery, chemotherapy and radiotherapy, which are available depending mostly on disease stage. However, patients with advanced CRC have lost the chance of surgery，may also have a worse life because of chemotherapy and radiotherapy. With more and more studies on targeted therapy, such as Bevacizumab and Cetuximab, may shines a light for the patients with CRC. Chemotherapy combined with targeted therapy has become a new direction for the treatment of advanced CRC. Moreover, the association between tumor location and targeted therapy has become a hot topic. This review focuses on the progress of monoclonal antibody in the first-and second-tier treatment of advanced CRC and the effect of the left and right half colon on the efficacy of targeted drugs.
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2017, Vol. 14 
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