帕金森病18 F-FDG PET成像研究进展
陈志琳 汪锡金
上海交通大学医学院附属新华医院神经内科,上海 200092
18 F-FDG PET imaging in Parkinson's disease
CHEN Zhilin WANG Xijin
Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiaotong University Medical College, Shanghai 200092, China
摘要 帕金森病是一种常见的神经系统变性疾病,早期诊断和鉴别诊断历来是神经科临床工作的难点之一,随着功能影像学的发展,18F-氟脱氧葡萄糖(FDG)正电子发射断层扫描成像(PET)成为帕金森病临床诊疗中的重要工具。本文回顾了目前18 F-FDG PET成像常用数据分析方法及帕金森病临床症状和脑代谢之间的研究结果,并对18 F-FDG PET成像在帕金森病的鉴别诊断、早期诊断和疗效评估以及未来发展方向进行综述。
关键词 :
帕金森病 ,
18 F-FDG PET ,
脑代谢网络模式 ,
认知功能损害 ,
快速眼动睡眠行为障碍
Abstract :Parkinson's disease is a common neurological degenerative disease, early diagnosis and differential diagnosis are the most difficult points toneurologist. With the development of functional imaging, 18 F labelled fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has become an important tool for Parkinson's disease. This artical first review the current analytic approaches to 18F-FDG PET imaging data and then discuss how 18 F-FDG PET studies have advanced understanding of the relation between the clinical symptoms and brain metabolism of Parkinson's disease. In addition,the value of 18F-FDG PET imaging in differential diagnosis, early diagnosis,the evaluation of treatment effects and the future development direction are also reviewed.
Key words :
Parkinson's disease
18 F-FDG PET
Metabolic pattern
Cognitive impairment
Idiopathic rapid eye movement sleep behavior disorders
基金资助: 国家自然科学基金资助项目(81671273)。
通讯作者:
汪锡金(1971.1-),男,博士,副主任医师,硕士研究生导师;研究方向:神经内科疾病。
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