米色脂肪与疾病的关系及其意义

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摘要人体中除了储存能量的白色脂肪外，还有特化的产热型脂肪组织，包括经典棕色脂肪和米色脂肪两种。不同于啮齿类动物经典棕色脂肪的终身存在，人类的经典棕色脂肪组织成人期会退化几乎消失，但米色脂肪在寒冷刺激、过量儿茶酚胺或β肾上腺素能受体激动剂等处理后分散存在于白色脂肪中并代谢产热，可能在开发针对肥胖及其相关的2型糖尿病治疗靶点方面发挥潜在作用。因此，本文对现阶段米色脂肪与肥胖、糖尿病、脂肪肝、肿瘤等疾病的关系研究进行简单回顾，并对其进行分析和总结，为米色脂肪的进一步研究和应用奠定基础。

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	马雷李令一杨中汉▲

关键词 ：米色脂肪, 肥胖, 糖尿病, 脂肪肝, 肿瘤

Abstract：Besides energy-stocking white adipose tissue, there are two types of thermogenic adipose tissues including classical brown adipose tissue and beige adipose tissue. Human classical brown adipose tissue may regress by adulthood and almost disappear, which is distinct from rodent animal life-through existence. Beige adipocytes sporadically reside with white adipocytes and emerge in response to certain environmental cues, such as chronic cold exposure, excess catecholamine or β-adrenergic stimulation. Beiging of adipose tissue may play a potential role in developing an attractive therapeutic target for obesity and obesity-associated diseases, including type 2 diabetes. In this paper, we review, analyze and summarize the present research on the beige fat and obesity, diabetes, fatty liver, tumor and other diseases, for the further research and application of beige adipose tissue.

Key words： Beige adipose Obesity Diabetes Fatty liver Tumor

基金资助:国家自然科学基金资助项目（81570764）。

通讯作者: ▲通讯作者

引用本文:

马雷李令一杨中汉▲. 米色脂肪与疾病的关系及其意义[J]. 中国医药导报, 2017, 14(25): 30-33.
MA Lei LI Lingyi YANG Zhonghan▲. The relationship between beige fat and disease and its significance. 中国医药导报, 2017, 14(25): 30-33.

链接本文:

http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2017/V14/I25/30

[1] Barbatelli G，Murano I，Madsen L，et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation [J]. Am J Physiol Endocrinol Metab，2010，298（6）：E1244-E1253.
[2] Lagowska K，Jeszka J. Adiposetissueas an endocrineorgan [J]. J Clin Endocrinol Metab，2004，89（4）：639-651.
[3] Chmelar J，Chung KJ，Chavakis T. The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance [J]. Thromb Haemost，2013， 109（3）：399-406.
[4] Cypess AM，Lehman S，Williams G，et al. Identification and importance of brown adipose tissue in adult humans [J]. N Engl J Med，2009，360（15）：1509-1517.
[5] Virtanen K，Lidell MJ，Heglind M，et al. Functional brown adipose tissue in healthy adults [J]. N Engl J Med，2009， 360（15）：1518-1525.
[6] van Marken Lichtenbelt WD，Vanhommerig JW，Smulders NM，et al. Cold activated brown adipose tissue in healthy men [J]. N Engl J Med，2009，360：1500-1508.
[7] Cohen P，Spiegelman BM. Brown and beige fat：molecular parts of a thermogenic machine [J]. Diabetes，2015，64（7）：2346-2351.
[8] 高洋，魏著英，白春玲，等.哺乳动物脂肪细胞的分化及调控[J].中国细胞生物学学报，2015（12）：1708-1712.
[9] Wu J，Bostr■m P，Sparks L，et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human [J]. Cell，2012，150（2）：366-376.
[10] Wu J，Cohen P，Spiegelman BM. Adaptive thermogenesis in adipocytes：is beige the new brown? [J]. Genes Dev，2013，27（3）：234-250.
[11] 汪凯，任安经，章卫平.米色脂肪：一种新型的脂肪[J].第二军医大学学报，2014，35（2）：195-199.
[12] Seale P，Bjork B，Yang W，et al. PRDM16 controls a brown fat/skeletal muscle switch [J]. Nature，2008，454（7207）：961-967.
[13] Lee YH，Petkova AP，Mottillo EP，et al. In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding [J]. Cell Metab，2012，15（4）：480-491.
[14] Sharp LZ，Shinoda K，Ohno H，et al. Human BAT possesses molecular signatures that resemble beige/brite cells [J]. PLoS One，2012，7（11）：e49452.
[15] de Jong JM，Larsson O，Cannon B，et al. A stringent validation of mouse adipose tissue identity markers [J]. Am J Physiol Endocrinol Metab，2015，308（12）：E1085-E1105.
[16] Peirce V，Carobbio S，Vidalpuig A. The different shades of fat [J]. Nature，2014，510（7503）：76-83.
[17] Gregg EW，Shaw JE. Global health effects of overweight and obesity [J]. N Engl J Med，2017，377（1）：80-81.
[18] Bartelt A，Heeren J. The holy grail of metabolic disease：brown adipose tissue [J]. Curr Opin Lipidol，2012，23（3）：190-195.
[19] Bartelt A，Bruns OT，Reimer R，et al. Brown adipose tissue activity controls triglyceride clearance [J]. Nat Med，2011，17（2）：200-205.
[20] Stanford KI，Middelbeek RJ，Townsend KL，et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity [J]. J Clin Invest，2013，123（1）：215-223.
[21] Vernochet C，Mcdonald ME，Farmer SR. Brown adipose tissue：a promising target to combat obesity [J]. Drug News Perspect，2010，23（7）：409-417.
[22] Lizcano F，Vargas D. Biology of beige adipocyte and possible therapy for type 2 diabetes and obesity [J]. Int J Endocrinol，2016，2016（12）：1-10.
[23] Bartelt A，Merkel M，Heeren J. A new，powerful player in lipoprotein metabolism：brown adipose tissue [J]. J Mol Med（Berl），2012，90（8）：887-893.
[24] Chondronikola M，Volpi E，B?覬rsheim E，et al. Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans [J]. Diabetes，2014，63（12）：4089-4099.
[25] Lee P，Smith S，Linderman J，et al. Temperature-acclimated brown adipose tissue modulates insulin sensitivity in humans [J]. Diabetes，2014，63（11）：3686-3698.
[26] Guerra C，Navarro P，Valverde AM，et al. Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance [J]. J Clin Invest，2001，108（8）：1205-1213.
[27] Gunawardana SC，Piston DW. Insulin-independent reversal of type 1 diabetes in non-obese diabetic mice with brown adipose tissue transplant [J]. Am J Physiol Endocrinol Metab，2015，308（12）：E1043-E1045.
[28] Bartelt A，Bruns OT，Reimer R，et al. Brown adipose tissue activity controls triglyceride clearance [J]. Nat Med，2011，17（2）：200-205.
[29] Berbée JFP，Boon MR，Khedoe PP，et al. Brown fat activation reduces hypercholesterolemia and protects from atherosclerosis development [J]. Nat Commun，2015，6：6356.
[30] Jc VDB，Boon MR，Steenbergen J，et al. Cold exposure partially corrects disturbances in lipid metabolism in a male mouse model of glucocorticoid excess [J]. Endocrinology，2015，156（11）：4115-4128.
[31] Yilmaz Y，Ones T，Purnak T，et al. Association between the presence of brown adipose tissue and non-alcoholic fatty liver disease in adult humans [J]. Aliment Pharmacol Ther，2011，34（3）：318-323.
[32] Ozguven S，Ones T，Yilmaz Y，et al. The role of active brown adipose tissue in human metabolism [J]. Eur J Nucl Med Mol Imaging，2016，43（2）：355-361.
[33] Frontini A，Vitali A，Perugini J，et al. White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma [J]. Biochim Biophys Acta，2013，1831（5）：950-959.
[34] Vergnes L，Davies GR，Lin JY，et al. Adipocyte browning and higher mitochondrial function in periadrenal but not SC fat in pheochromocytoma [J]. J Clin Endocrinol Metab，2016，101（11）：4440-4448.
[35] Wang F，Gao S，Chen F，et al. Mammary fat of breast cancer：gene expression profiling and functional characterization [J]. PLoS One，2014，9（10）：e109742.
[36] Pervin S，Singh R，Parveen M，et al. Increased expression of beige/brown adipose markers from host and breast cancer cells influence xenograft formation in mice [J]. Mol Cancer Res，2016，14（1）：78-92.
[37] Chatzigeorgiou A，Chavakis T. Immune cells and metabolism [J]. Handb Exp Pharmacol，2016，233：221-249.
[38] Ip BC，Hogan AE，Nikolajczyk BS. Lymphocyte roles in metabolic dysfunction：of men and mice [J]. Trends Endocrinol Metab，2015，26（2）：91-100.
[39] Lee MW，Odegaard J，Mukundan L，et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis [J]. Cell，2015，160（1-2）：74-87.
[40] Kim J，Kim W，Moon UJ，et al. Intratumorally establishing type 2 innate lymphoid cells blocks tumor growth [J]. J Immunol，2016，196（5）：2410-2423.
[41] Hondares E，Gallego-Escuredo JM，Flachs P，et al. Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue [J]. Metabolism，2014，63（3）：312-317.
[42] Scheele C，Nielsen S. Metabolic regulation and the anti-obesity perspectives of human brown fat [J]. Redox Biol，2017，12：770-775.