Abstract：Objective To investigate the clinical efficacy of oral administration of Clostridium butyricum powder in the treatment of neonatal pathological jaundice. Methods Eighty term newborns with pathological jaundice born in the Department of Pediatrics of People′s Hospital of Dachang Hui Autonomous County from January 2015 to January 2016 were selected, and they were divide into control group and observation group by randomized digital table, with 40 cases in each group. The newborns in the control group were received routine treatment such as blue light therapy and liver enzyme inducer. In the observation group, the neonates were taken twice daily on the basis of conventional treatment, and 500 mg of Clostridium butyricum powder was taken daily for 5 days. The changes of serum total bilirubin levels before and after treatment were observed in both groups, and the daily bilirubin levels, peak bilirubin concentrations, duration of jaundice, and yellowing of the inner tube within 72 h were compared. Results There was no significant difference in serum total bilirubin levels between the two groups before treatment (P > 0.05). After treatment, the peak serum bilirubin concentration in the observation group was significantly lower than that in the control group, and the incidence of newborns with hyperbilirubinemia was 17.5%, which was lower than that of the control group (40.0%), the difference was statistically significant (P < 0.05). The daily decrease in neonatal serum bilirubin in the observation group was significantly higher than that in the control group, the difference was statistically significant (P < 0.01). After treatment, the duration of jaundice in the observation group was significantly shorter than that of the control group and the rate of yellowing of the inner tuberculosis within 72 h after birth was significantly higher than that of the control group, the difference was statistically significant (P < 0.05). Conclusion Oral administration of Clostridium butyricum powder, as an adjuvant therapy, can effectively reduce the level of bilirubin in the serum of pathological jaundice newborns and shorten the duration of neonatal jaundice, and it is worthy of clinical application.
2018, Vol. 15 
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