Endoplasmic reticulum stress related reactive oxygen species and its mechanism
SUN Jing1 WANG Wei2 TIAN Ye2 TIAN Zhen1▲
1.Department of Pathophysiology, Harbin Medical University, Heilongjiang Province, Harbin 150081, China;
2.Department of Cardiovascular Medicine, the Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, Harbin 150001, China
Abstract：Endoplasmic reticulum(ER) is the major site of calcium storage and protein folding. Alterations in the oxidative environment of ER and also intra-ER Ca2+ can cause the production of ERS-induced ROS. PDI, ERO-1, GSH, Nox4, CYP, Ca2+ and mitochondrial electron transport chain proteins play crucial roles in ERS-induced production of ROS. Here, persistent ERS and protein misfolding-initiated ROS cascades and their related mechanisms will be reviewed.
[1] Barlowe CK，Miller EA. Secretory protein biogenesis and traffic in the early secretory pathway [J]. Genetics，2013， 193（2）：383-410.
[2] Duncan MJ，Stanley M，Parkhouse N，et al. Acute caffeine ingestion enhances strength performance and reduces perceived exertion and muscle pain perception during resistance exercise [J]. Eur J Sport Sci，2013，13（4）：392-399.
[3] Araki K，Nagata K. Functional in vitro analysis of the ERO1 protein and protein-disulfide isomerase pathway [J]. J Biol Chem，2011，286（37）：32 705-32 712.
[4] Wan S，Jiang L. Endoplasmic reticulum（ER）stress and the unfolded protein response（UPR）in plants [J]. Protoplasma，2016，253（3）：753-764.
[5] Cao SS，Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease [J]. Antioxid Redox Signal，2014，21（3）：396-413.
[6] Zheng W，Wang B，Si M，et al. Zearalenone altered the cytoskeletal structure via ER stress- autophagy- oxidative stress pathway in mouse TM4 Sertoli cells. [J]. Sci Rep，2018，8（1）：3320.
[7] Korge P，Calmettes G，John SA，et al. Reactive oxygen species production induced by pore opening in cardiac mitochondria：the role of complex Ⅲ [J]. J Biol Chem，2017，292（24）：9882-9895.
[8] Kleniewska P，Piechota A，Skibska B，et al. The NADPH oxidase family and its inhibitors [J]. Arch Immunol Ther Exp（Warsz），2012，60（4）：277-294.
[9] Simplicio JA，do Vale GT，Gonzaga NA，et al. Reactive oxygen species derived from NAD（P）H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries [J]. J Physiol Biochem，2017，73（1）：5-16.
[10] Santos CX，Tanaka LY，Wosniak J，et al. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response：roles of endoplasmic reticulum oxidoreductases，mitochondrial electron transport，and NADPH oxidase [J]. Antioxid Redox Signal，2009，11（10）：2409-2427.
[11] Lu P，Zhang CC，Zhang XM，et al. Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice [J]. J Huazhong Univ Sci Technolog Med Sci，2017，37（5）：744-749.
[12] Chen L，Zhao M，Li J，et al. Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1 [J]. Cell Cycle，2017，16（4）：348-359.
[13] Loughlin DT，Artlett CM. Precursor of advanced glycation end products mediates ER-stress-induced caspase-3 activation of human dermal fibroblasts through NAD（P）H oxidase 4 [J]. PLoS One，2010，5（6）：e11 093.
[14] Yang HC，Yang CH，Huang MY，et al. Homology modeling and molecular dynamics simulation combined with X-ray solution scattering defining protein structures of thromboxane and prostacyclin synthases [J]. J Phys Chem B，2017，121（50）：11 229-11 240.
[15] Miwa GT，West SB，Huang MT，et al. Studies on the association of cytochrome P-450 and NADPH-cytochrome c reductase during catalysis in a reconstituted hydroxylating system [J]. J Biol Chem，1979，254（13）：5695-5700.
[16] Morlock LK，Bottcher D，Bornscheuer UT. Simultaneous detection of NADPH consumption and H2O2 production using the Ampliflu Red assay for screening of P450 activities and uncoupling [J]. Appl Microbiol Biotechnol，2018，102（2）：985-994.
[17] Raturi A，Simmen T. Where the endoplasmic reticulum and the mitochondrion tie the knot：the mitochondria-associated membrane（MAM）[J]. Biochim Biophys Acta，2013，1833（1）：213-224.
[18] Radermacher KA，Wingler K，Langhauser F，et al. Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress [J]. Antioxid Redox Signal，2013，18（12）：1418-1427.
[19] Chen Y，Lewis W，Diwan A，et al. Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy [J]. Proc Natl Acad Sci USA，2010，107（20）：9035-9042.
[20] Sitia R，Molteni SN. Stress，protein（mis）folding，and signaling：the redox connection [J]. Sci STKE，2004（239）：pe27.
[21] Le Moal E，Groussard C，Paillard T，et al. Redox status of professional soccer players is influenced by training load throughout a season [J]. Int J Sports Med，2016，37（9）：680-686.
[22] Ponsero AJ，Igbaria A，Darch MA，et al. Endoplasmic reticulum transport of glutathione by Sec61 is regulated by Ero1 and Bip [J]. Mol Cell，2017，67（6）：962-973.
[23] Di S，Fan C，Yang Y，et al.Activation of endoplasmic reticulum stress is involved in the activity of icariin against human lung adenocarcinoma cells [J]. Apoptosis，2015，20（9）：1229-1241.
[24] Park WH. Gallic acid inhibits the growth of calf pulmonary arterial endothelial cells through cell death and glutathione depletion [J]. Mol Med Rep，2017. DOI：10.3892/mmr.2017.7585.
[25] Bravo R，Vicencio JM，Parra V，et al. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress [J]. J Cell Sci，2011，124（Pt 13）：2143-2152.
[26] Meares GP，Hughes KJ，Naatz A，et al. IRE1-dependent activation of AMPK in response to nitric oxide [J]. Mol Cell Biol，2011，31（21）：4286-4297.
[27] Moserova I，Kralova J. Role of ER stress response in photodynamic therapy：ROS generated in different subcellular compartments trigger diverse cell death pathways [J]. PLoS One，2012，7（3）：e32972.
2018, Vol. 15 
京公网安备 11010502046598号