Abstract：Objective To explore the expression of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) and its clinical significance. Methods A total of 97 patients with sudden deafness admitted to Nanjing Integrated Traditional Chinese and Western Medicine Hospital from January 2016 to June 2017 were selected as the case group, 60 healthy subjects were randomly selected as the control group at the same period. The serum sVCAM-1 level in the two groups was measured by the enzyme-linked immunosorbent assay, in addition, the relationship between sVCAM-1 with patients' demographic data and the diagnostic value of sVCAM-1 for sudden deafness were analyzed. Results The serum sVCAM-1 level in the case group was higher than that of control group, with statistically significant difference (P ＜ 0.05). The sVCAM-1 level of patients at the age≥45 was higher than the age＜45, and sVCAM-1 level in patients with severe hearing loss was more higher, and sVCAM-1 level in patients with total deafness type was more higher than those in other types, sVCAM-1 level of patients with upper respiratory tract infection and cardiovascular complications were more higher, with statistically significant differences (P ＜ 0.05). The ROC area of sVCAM-1 in the diagnosis of sudden deafness was 0.904 (95%CI：0.841-0.967), the sensitivity was 76.5% and the specificity was 91.8%, the best truncation value of sVCAM-1 at this time was 579.23 ng/mL. Conclusion The serum sVCAM-1 in patients with sudden deafness is significantly elevated, which is closely related to age, hearing loss, hearing curve, upper respiratory tract infection and cerebrovascular complications. Early detection can effectively predict the occurrence of sudden deafness.
杨明 伏飞达 朱晓燕. 突发性耳聋患者血清sVCAM-1水平变化及其意义[J]. 中国医药导报, 2018, 15(15): 119-122.
YANG Ming FU Feida ZHU Xiaoyan. Changes and significance of serum sVCAM-1 level in patients with sudden deafness. 中国医药导报, 2018, 15(15): 119-122.
[1] Bulgurcu S，Dikilitac B，Arslan IB，et al. Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Pediatric Patients with IdiopathicSudden Hearing Loss [J]. J Int Adv Otol，2017，13（2）：217-220.
[2] 许航宇，舒海荣，宋建新.老年突发性耳聋患者血清可溶性血管细胞黏附分子-1水平及其影响因素[J].中国老年学杂志，2017，37（2）：452-453.
[3] Schreiber BE，Agrup C，Haskard DO，et al. Sudden sensorineural hearing loss [J]. Lancet，2010，375（9721）：1203-1211.
[4] Ito T，Li X，Kurima K，et al. Slc26a4-insufficiency causes fluctuating hearing loss and striavascularis dysfunction [J]. Neurobiol Dis，2014，66（2）：53-65.
[5] Shih CP，Chou YC，Chen HC，et al. Analysis of caloric test responses in sudden hearing loss [J]. Ear Nose Throat J，2017， 96（2）：59-64.
[6] 潘凌云，朱贵月，马晓静，等.老年急性冠脉综合征患者血清sICAM-1、sVCAM-1变化及影响因素和瑞舒伐他汀的干预作用[J].中国老年学杂志，2011，31（1）：38-40.
[7] Shim BJ，Lee DH，Youn HJ. Increased soluble vascular adhesion molecule-1 concentration is associated with impaired coronary flow reserve in cardiac syndrome X [J]. Heart Vessels，2014，29（6）：723-731.
[8] 中华耳鼻咽喉头颈外科杂志编辑委员会，中华医学会耳鼻咽喉头颈外科学分会.突发性聋的诊断和治疗指南（2005年，济南）[J].中华耳鼻咽喉头颈外科杂志，2006，41（8）：569.
[9] 汪吉宝，段家德，陈海华，等.听神经病106例听力学分析[J].中华耳鼻咽喉头颈外科杂志，2008，43（5）：347-350.
[10] 陈黎黎，江黎珠，胡国平.突发性耳聋预后相关影响因素的分析[J].第三军医大学学报，2015，37（11）：1141-1145.
[11] Min SK，Shin JH，Chang MY，et al. Impact of control of blood glucose level during treatment of sudden deafness in diabetics：relationship with prognosis [J]. Eur Arch Otorhinolaryngol，2017，274（3）：1339-1343.
[12] Liebau A，Pogorzelski O，Salt AN，et al. HearingChanges After Intratympanically Applied Steroids for Primary Therapy ofSudden Hearing Loss：A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols [J]. Otol Neurotol，2017，38（1）：19-30.
[13] Kim SH，Jung AR，Kim SI，et al. Refractory Granulomatosis with Polyangiitis Presenting as Facial Paralysis and Bilateral?Sudden Deafness [J]. J Audiol Otol，2016，20（1）：55-58.
[14] Cochran DB，Gray LN，Anderson KW，et al. Degradable poly（apigenin） polymer inhibits tumor cell adhesion to vascular endothelial cells [J]. J Biomed Mater Res B Appl Biomater，2016，104（7）：1438-1447.
[15] Kocijancic M，Cubranic Z，Vujicic B，et al. Solubleintracellularadhesionmolecule-1 and omentin-1 as potential biomarkers of subclinicalatherosclerosisin hemodialysis patients [J]. Int Urol Nephrol，2016，48（7）：1145-1154.
[16] Lisowska A，Siergiejko E，Tycinska A，et al. sVCAM-1concentration and carotid IMT values in patients with acute myocardial infarction-Atherosclerotic markers of the presence，progress and prognosis [J]. Adv Med Sci，2015，60（1）：101-106.
[17] Quaranta N，Ramunni A，Brescia P，et al. Solubleintercellularadhesionmolecule 1 and soluble vascular cell adhesion molecule 1 insudden hearing loss [J]. Otol Neurotol，2008，29（4）：470-474.
[18] Atay G，Kayahan B，cinar Bc，et al. Prognostic Factors in Sudden Sensorineural Hearing Loss [J]. Balkan Med J，2016， 33（1）：87-93.
[19] Orndorff RL，Hong N，Yu K，et al. NOX2 in lung inflammation：quantum dot based in situ imaging of NOX2-mediated expression of vascular cell adhesion molecule-1 [J]. Am J Physiol Lung Cell Mol Physiol，2014，306（3）：L260-L268.
[20] Kim SH，Kim SJ，Im H，et al. A Trend in Sudden Sensorineural Hearing Loss：Data from a Population-Based Study [J]. Audiol Neurootol，2018，22（6）：311-316.
[21] Kim JY，Hong JY，Kim DK. Association of Sudden Sensor ineural Hearing Loss With Risk of Cardiocerebrovascular Disease：A Study Using Data From the Korea National Health Insurance Service [J]. JAMA Otolaryngol Head Neck Surg，2018，144（2）：129-135.
2018, Vol. 15 
京公网安备 11010502046598号