Epidemiological characteristics and risk factors of T2DM in premenopausal and postmenopausal women
LI Qingjun1 WANG Xiaoqing2 HU Wen2 YU Weinan2
1.Xuzhou Medical College, Jiangsu Province, Xuzhou 221004, China;
2.Department of Endocrinology, the Second People′s Hospital of Huai′an, Huai′an Affiliated Hospital of Xuzhou Medical University, Jiangsu Province, Huai′an 223002, China
Abstract：Objective To analyze the prevalence of type 2 diabetes mellitus (T2DM) in premenopausal and postmenopausal women and providing effective data for the prevention and intervention of the occurrence and development of T2DM. Methods A total of 3227 women with T2DM met the requirements from June to December in 2014 were selected, they were divided into two groups according to the questionnaire, including 207 cases of premenopausal women and 3020 cases of postmenopausal women. The prevalence of T2DM and the associated risk factors in the two groups were analyzed. Results Prevalence of premenopausal women with T2DM was 12.1% while the prevalence in postmenopausal state was 19.4%, the difference was statistically significant (P < 0.05). The serum total protein (TP) was a major risk factor for premenopausal women with T2DM (OR=1.16, 95%CI: 1.02-1.32, P < 0.05). In postmenopausal women, the prevalence of T2DM was associated with age (OR=1.04, 95%CI: 1.02-1.05, P < 0.05), BMI(OR=1.08, 95%CI: 1.04-1.11, P < 0.05), Triglyceride (TG) (OR=1.11, 95%CI: 1.03-1.20, P < 0.05), blood urea nitrogen (BUN) (OR=1.07, 95%CI: 1.00-1.13, P < 0.05), alanine aminotransferase (ALT) (OR=1.01, 95%CI: 1.00-1.02, P < 0.05), TP (OR=1.03, 95%CI: 1.01-1.06, P < 0.05)and blood pressure (OR=1.52, 95%CI: 1.23-1.88, P < 0.05). Conclusion Postmenopausal women with type 2 diabetes have a higher rate than premenopausal women. TP is a major risk factor for premenopausal women with T2DM. Postmenopausal risk factors in addition to traditional risk factors such as lipidemia, blood pressure, TP, ALT, and BUN. Risk factors should be monitored, and prevention and intervention measures should be taken early to reduce the prevalence of diabetes and improve the quality of life of women before and after menopause.
李清珺1 王小清1 胡文2 俞伟男2. 绝经前后女性2型糖尿病流行病学特点及危险因素分析[J]. 中国医药导报, 2018, 15(15): 8-12.
LI Qingjun1 WANG Xiaoqing2 HU Wen2 YU Weinan2. Epidemiological characteristics and risk factors of T2DM in premenopausal and postmenopausal women. 中国医药导报, 2018, 15(15): 8-12.
[1] 中华医学会糖尿病学分会.中国2型糖尿病防治指南（2013年版）[J].中国医学前沿杂志：电子版，2015，7（3）：26-89.
[2] Yan F，Liu J，Zhao X，et al. Association of the Number of Years Since Menopause with Metabolic Syndrome and Insulin Resistance in Chinese Urban Women [J]. J Womens Health，2015，24（10）：843-848.
[3] Medarametla DS. Early Menopause in Type 2 Diabetes - A Study from a South Indian Tertiary Care Centre [J]. J Clin Diagnostic Res，2015，9（10）：OC08-10.
[4] Ding EL，Song Y，Manson JE，et al. Plasma sex steroid hormones and risk of developing type 2 diabetes in women： a prospective study [J]. Diabetologia，2007，50（10）：2076-2084.
[5] Gracia CR，Sammel MD，Freeman EW，et al. Defining menopause status：creation of a new definition to identify the early changes of the menopausal transition [J]. Menopause，2005，12（2）：128-135.
[6] American Diabetes Association.. Standards of medical care in diabetes--2012 [J]. Diabetes Care，2012，35 Suppl 1：S11-S63.
[7] Wedisinghe L，Perera M. Diabetes and the menopause[J]. Maturitas，2009，63（3）：200-203.
[8] Heianza Y，Arase Y，Kodama S，et al. Effect of Postmenopausal Status and Age at Menopause on Type 2 Diabetes and Prediabetes in Japanese Individuals：Toranomon Hospital Health Management Center Study 17 （TOPICS 17） [J]. Diabetes Care，2013，36（12）：4007-4014.
[9] 杨云霞，朱习海，王刚.某地区健康成人血清总蛋白及清蛋白测定结果的分析[J].检验医学与临床，2013，10（4）：413-414.
[10] 葛声，蔡东联，唐彦，桂腊梅，曹芸. 采用主成分分析法对糖尿病住院患者营养状况综合评价[J].中国临床营养杂志，2005，13（5）：285-288.
[11] 丁振.肝功与血清学指标水平检验在脂肪肝诊断中的应用[J].中外医疗，2016，35（25）：23-24.
[12] Yin M，Wheeler M，Kono H，et al. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice [J]. Gastroenterology，1999，117（4）：942-952.
[13] McCaleb ML，Wish JB，Lockwood DH. Insulin resistance in chronic renal failure [J]. Endocr Res，1985，11（1-2）：113-125.
[14] Vozarova B，Stefan N，Lindsay RS，et al. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes [J]. Diabetes，2002，51（6）：1889-1895.
[15] Xie Y，Bowe B，Li T，et al. Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus [J]. Kidney Int，2017，93（3），741-752.
[16] Thomas SS，Zhang L，Mitch WE. Molecular Mechanisms of Insulin Resistance in Chronic Kidney Disease [J]. Kidney Int，2015，88（6）：1233-1239.
[17] Koppe L，Pelletier CC，Alix PM，et al. Insulin resistance in chronic kidney disease：new lessons from experimental models [J]. Nephrology，dialysis，transplantation：official publication of the European Dialysis and Transplant Association-European Renal Association，2014，29（9）：1666-1674.
[18] Pham H，Robinson-Cohen C，Biggs ML，et al. Chronic kidney disease，insulin resistance，and incident diabetes in older adults [J]. Clin J Am Soc Nephrol，2012，7（4）：588-594.
[19] de Boer IH，Zelnick L，Afkarian M，et al. Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD [J]. J Ame Soc Nephrol，2016，27（9）：2861-2871.
[20] Koppe L，Nyam E，Vivot K，et al. Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease [J]. J Clin Invest，2016，126（9）：3598-3612.
2018, Vol. 15 
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