Evaluation and application of nutritional and immune status in the perioperative period of colorectal cancer
GUO Fei1 ZHANG Xiaoyang2 LV Yanqin1 WU Xueliang1 SUN Guangyuan1 LI Minghui1 XUE Jun1▲
1.Department of General Surgery, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of Physical Examination, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China
Abstract：Objective To analyze the perioperative nutritional and immune status of colorectal cancer, and to provide evidence for clinical application. Methods From January 2014 to 2016 December, 100 cases of rectal cancer treated in the First Affiliated Hospital of Hebei North University were divided into intervention group and control group with random envelopes, with 50 cases in each group. The control group was treated with routine intervention, and the intervention group was intervened with nutritional support scheme. One d and 7 d before operation, 1, 4, 8 d and 15 d after operation. The levels of CD3+ T cells, CD4+ T cells, CD8+ T cells, IgG, IgA, IgM, ALB, PA, Hb and TF were counted, and the incidence of adverse reactions was statistically analyzed. Results Compared with 1 d before operation, the proportion of CD3+ and CD4+ T cells of the two groups was significantly decreased at 1 d after the operation, and the proportion of CD8+ T cells was significantly higher than that of 1 d before the operation, the differences were statistically significant (P < 0.05). The proportion of CD3+ and CD4+ T cells in the intervention group was significantly higher than those of the control group, and the CD8+ T cells was significantly lower than that of the control group, the differences were statistically significant (P < 0.05). One day after the operation, the levels of IgG, IgA and IgM of the two groups were lower than those 1 d before the operation, and the differences were statistically significant (P < 0.05), 4 d after the operation. The level of standard mean improvement of two groups was significantly higher than that of 1 d after operation (P < 0.05), and the level of IgG, IgA and IgM in the blood of the intervention group was significantly higher than that of the control group at 15 d after the operation, and the difference was statistically significant (P < 0.05). The levels of ALB, PA, TF and Hb of the two groups were significantly lower than those of 1 d before the operation, and the difference was significantly lower than the 1 d before the operation, the differences were statistically significant (P < 0.05). Four days after the operation, each index in the two groups were better than 1 d after the operation, the differences were statistically significant (P < 0.05), and the levels of ALB, PA, TF and Hb of the intervention group were significantly higher than those of the control group at 15 d after the operation, and the differences were statistically significant (P < 0.05). The total incidence of reaction was significantly lower than that of the control group, the difference was statistically significant (P < 0.05). Conclusion Nutrition supplementation in the perioperative period of colorectal cancer patients can effectively improve the nutritional and immune status of the patients and reduce the incidence of adverse reactions in patients.
郭飞1 张晓阳2 吕燕琴1 武雪亮1 孙光源1 李明辉1 薛军1▲. 结直肠癌围术期营养干预对患者术后营养指标及免疫功能的影响[J]. 中国医药导报, 2018, 15(14): 71-75.
GUO Fei1 ZHANG Xiaoyang2 LV Yanqin1 WU Xueliang1 SUN Guangyuan1 LI Minghui1 XUE Jun1▲. Evaluation and application of nutritional and immune status in the perioperative period of colorectal cancer. 中国医药导报, 2018, 15(14): 71-75.
2018, Vol. 15 
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