Abstract：Objective To investigate effect of macrophages and pulmonary microvascular endothelial cells (HPMVECs) on Aspergillus fumigatus. Methods In vitro models of Aspergillus fumigatus-treated HPMVECs and Aspergillus fumigatus-treated J774 cells were established, confocal laser scanning microscope was used for detection of co-cultures. Results Aspergillus fumigatus were phagocyted by J774 cells. However, Aspergillus fumigatus were not internalized by HPMVECs, onlu morphology change and integrity compromise were observed on Aspergillus fumigatus-treated HPMVECs. Conclusion J774 cells phagocytes Aspergillus fumigatus. HPMVECs can't internalize Aspergillus fumigatus. Aspergillus fumigatus can cause morphology change and integrity compromise in HPMVECs.
宋珺 韩菁 孙越 施伟民▲. 巨噬细胞和肺微血管内皮细胞对烟曲霉作用的研究[J]. 中国医药导报, 2018, 15(13): 18-20.
SONG Jun HAN Jing SUN Yue SHI Weimin▲. Effect of macrophages and pulmonary microvascular endothelial cells on Aspergillus fumigatus. 中国医药导报, 2018, 15(13): 18-20.
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2018, Vol. 15 
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