Effect of cocktail drug injection on blood loss and safety evaluation after primary total knee arthroplasty
BI Chunqiang1 WEN Jianmin2 ZHANG Hui1 YANG Dawei1 SONG Xue1 LI Duoduo3
1.Second Department of Orthopaedics, Guang′anmen Hospital South District of China Academy of Chinese Medicine Sciences, Beijing 102618, China;
2.Second Department of Orthopaedics, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China;
3.Massage Department, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China
Abstract：Objective To investigate the effectiveness and safety of cocktail drug injection on blood loss and safety evaluation of local injection after primary total knee arthroplasty (TKA). Methods Ninety patients who received primary TKA from June 2015 to October 2016 in Guang′anmen Hospital South district of China Academy of Chinese Medicine Sciences was retrospectively analysed and divided into treatment group and control group, with 45 cases in each group. Treatment group was treated with cocktail drug injection around knee joint capsule and 50 mL intra-articular injection, the control group were treated with saline intra-articular infusion. The bone wax was used to stop the bleeding in the two groups, and the drainage tube was clamped for 3 hours and removed 24 hours after the operation. Postoperative drainage, occult blood loss, prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ration (INR), D-dimer value and deep venous thrombosis cases were recorded in both group. Results The dominant blood loss and hidden hemorrhage in the treatment group were less than the control group, the number of blood transfusion was less than the control group, the differences were highly statistically significant (P ＜ 0.01). Both groups had no statistically significant in PT, APTT, INR, D-dimer value (P ＞ 0.05). The incidence of thrombosis was no statistically significant between the two groups (P ＞ 0.05). Conclusion The cocktail drug injection thearapy is an effective and safe method to control the amount of blood loss during the operation of primary TKA.
毕春强1 温建民2 张辉1 杨大伟1 宋雪1 李多多3. 鸡尾酒疗法对初次全膝关节置换术后失血量的影响及安全性评价[J]. 中国医药导报, 2018, 15(12): 65-68.
BI Chunqiang1 WEN Jianmin2 ZHANG Hui1 YANG Dawei1 SONG Xue1 LI Duoduo3. Effect of cocktail drug injection on blood loss and safety evaluation after primary total knee arthroplasty. 中国医药导报, 2018, 15(12): 65-68.
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2018, Vol. 15 
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