Clinical efficacy of minimally invasive transurethral plasmakinetic resection of prostate combined with endocrine therapy for elderly patients with advanced prostate cancer complicated by urinary retention
ZHANG Hong ZHANG Yu YI Faxian
Department of Urology, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010059, China
Abstract：Objective To explore the clinical effect of minimally invasive transurethral plasmakinetic resection of prostate (PKRP) combined with endocrine therapy in the treatment of elderly patients with advanced prostate cancer complicated by urinary retention, and its effects on international prostate symptom score (IPSS) and life quality. Methods The clinical data of 70 elderly patients with advanced prostate cancer complicated by urinary retention admitted to the Department of Urology, Affiliated Hospital of Inner Mongolia Medical University and underwent PKRP combined with endocrine therapy from October 2016 to October 2017 were retrospectively analyzed. The residual urine volume (RUV), maximum flow rate (Qmax), prostate specific antigen (PSA), the scores of IPSS and life quality in the two groups were compared before and after treatment. Results After treatment, the RUV and PSA were significantly lower than those of before treatment, Qmax was significantly higher than that of before treatment, with highly statistically significant differences (P ＜ 0.01), the daily urination frequency, difficulty of holding urine and sense of incomplete urination were all significantly lower than those of before treatment, with highly statistically significant differences (P ＜ 0.01), the scores of life quality such as sleep quality, pain, fatigue and appetite were all significantly higher than those of before treatment, with highly statistically significant differences (P ＜ 0.01). Conclusion PKRP combined with endocrine therapy can effectively improve the urethral function, relieve the symptom and promote the life quality of elderly patients with advanced prostate cancer complicated by urinary retention.
张宏 张瑜 易发现. 微创经尿道前列腺等离子电切术联合内分泌治疗在高龄晚期前列腺癌并尿潴留患者中的效果[J]. 中国医药导报, 2018, 15(12): 45-47,52.
ZHANG Hong ZHANG Yu YI Faxian. Clinical efficacy of minimally invasive transurethral plasmakinetic resection of prostate combined with endocrine therapy for elderly patients with advanced prostate cancer complicated by urinary retention. 中国医药导报, 2018, 15(12): 45-47,52.
[1] 董柏君，王艳青，谢少伟，等.影像联合穿刺病理指导下靶向冷冻消融治疗局限性前列腺癌的临床应用[J].中华泌尿外科杂志，2017，38（6）：457-460.
[2] 陶凌松，陶良俊，陈弋生，等.晚期前列腺癌伴膀胱出口梗阻TURP或α1A受体阻滞剂联合内分泌治疗的疗效分析[J].中华男科学杂志，2015，21（7）：626-629.
[3] 翟忠奇，罗晓辉，汤正岐，等.晚期前列腺癌间歇与持续性内分泌治疗的临床观察[J].现代肿瘤医学，2015，23（4）：522-524.
[4] 卢慕峻，张克，张明，等.高危及局部晚期前列腺癌新辅助治疗后行腹腔镜下前列腺癌根治术的临床体会[J].中华临床医师杂志，2015，18（2）：196-199.
[5] 马海锋，张大海，郭冬，等.三维适形放疗联合内分泌治疗老年晚期前列腺癌临床疗效及对生活质量的影响[J].中国性科学，2015，21（3）：18-21.
[6] 彭冰，陈桂明.晚期前列腺癌的药物治疗研究进展[J].实用临床医药杂志，2016，20（15）：202-205.
[7] Berman-Booty LD，Knudsen KE. Models of neuroendocrine pro?鄄state cancer [J]. Endocr-relat cancer，2015，22（1）：R33-R49.
[8] 刘定益，胡桑，楚晨龙，等.微创经尿道前列腺等离子电切术联合内分泌治疗高龄晚期前列腺癌合并尿潴留[J].中国微创外科杂志，2017，17（10）：919-921.
[9] 池圣亮，李叶平.经尿道前列腺等离子电切术联合内分泌治疗晚期前列腺癌合并膀胱出口梗阻的疗效[J].中国性科学，2017，26（4）：14-16.
[10] Kool M，Fontein，DB，Meershoek-Klein KE，et al. Long term effects of extended adjuvant endocrine therapy on quality of life in breast cancer patients [J]. Breast，2015，24（3）：224-229.
[11] Lo AC，Truong PT，Wai ES，et al. Population-based analysis of the impact and generalizability of the NSABP-B24 study on endocrine therapy for patients with ductal carcinoma in situ of the breast [J]. Ann Oncol，2015，26（9）：1898-1903.
[12] 汪群锋，朱劲松，陈志洁，等.经尿道前列腺等离子双极电切术联合钬激光碎石治疗前列腺增生并膀胱结石的临床效果观察[J].临床医学，2015，35（2）：13-14.
[13] 韩聪祥，李金雨，林吓聪，等.分叶分隔法经尿道等离子双极电切术治疗大体积前列腺增生症[J].中国微创外科杂志，2015，19（5）：425-427，430.
[14] 刘冉录，张志宏，齐士勇，等.延迟局限性TURP治疗前列腺癌125I粒子植入术后尿潴留的疗效分析[J].中华泌尿外科杂志，2015，36（5）：350-353.
[15] 何青峰，吴娟，张景宇，等.晚期前列腺癌患者间歇性内分泌治疗的疗效观察[J].中国癌症杂志，2015，34（12）：989-993.
[16] 骆华春，傅志超，冯静，等.同期调强放疗联合内分泌治疗对局部晚期前列腺癌乏力症状的影响[J].肿瘤防治研究，2016，43（6）：502-507.
[17] 张继伟，王海涛，何群，等.125I粒子植入联合间歇性内分泌治疗局部中高危前列腺癌的临床分析[J].中国性科学，2015，28（4）：33-36.
[18] 裴昕奇，吴开杰，吕伟，等.晚期前列腺癌内分泌治疗血清睾酮浓度与疾病进展的关系[J].现代泌尿外科杂志，2017，22（5）：339-343.
[19] 严维刚，周智恩，周毅，等.局限性中高危前列腺癌近距离治疗联合内分泌治疗和外放疗的疗效分析[J].中华泌尿外科杂志，2017，38（6）：442-447.
[20] 姜良真，崔喆，王宝龙，等.间歇性内分泌治疗晚期前列腺癌的临床可行性及有效性[J].中国性科学，2017，26（6）：5-7.
[21] Rusz O，V?覺r?覺s A，Varga Z，et al. One-Year Neoadjuvant Endocrine Therapy in Breast Cancer [J]. Pathol Oncol Res，2015，21（4）：977-984.
[22] 王睿中.经尿道前列腺电切联合内分泌治疗晚期前列腺癌疗效分析[J].现代诊断与治疗，2015，11（5）：1159-1160.
[23] Rocca A，Farolfi A，Maltoni R，et al. Efficacy of endocrine therapy in relation to progesterone receptor and Ki67 expression in advanced breast cancer [J]. Breast Cancer Res Tr，2015，152（1）：57-65.
[24] 骆华春，傅志超，冯静，等.同期调强放疗联合内分泌治疗对局部晚期前列腺癌患者免疫指标的影响[J].现代肿瘤医学，2016，24（6）：939-942.
[25] 何岩，吴春磊，朱峰，等.经尿道前列腺电切术联合间歇性内分泌治疗晚期前列腺癌的疗效分析[J].中国现代医药杂志，2016，18（7）：10-12.
2018, Vol. 15 
京公网安备 11010502046598号