Application of Dexmedetomidine in painless gastroenteroscopy in elderly patients
BAO YU1 SHANG YU2
1.Department of Anesthesiology, Fuxin General Hospital of Liaoning Health Industry Group, Liaoning Province, Fuxin 123099, China;
2.Department of Anesthesiology, Air Force Hospital of the Northern Theater Command, Chinese People’s Liberation Army, Liaoning Province, Shenyang 110042, China
Abstract：Objective To investigate the application effect of Dexmedetomidine in painless gastroenteroscopy in elderly patients. Methods A total of 340 patients who underwent painless gastroenteroscopy in Fuxin General Hospital of Liaoning Health Industry Group from September 2018 to April 2019 were selected as the research objects, and they were divided into two groups according to random number table method, with 170 patients in each group. The control group was treated with 1.0 mg/kg Propofol intravenously + 0.1 μg/kg Fentanyl, and maintained with 2 mg/(kg·h) Propofol pump during gastroenteroscopy; observation group was additionally injected with Dexmedetomidine for 15 min at 30 μg. The induced dosage of Propofol and recovery time were compared between two groups; the heart rate (HR), mean arterial pressure (MAP), and oxygen saturation (SO2) of two groups were compared before administration (T0), before induction (T1), at the beginning of examination (T2), 10 min after examination (T3), and after examination when Stward score reached 6 points (T4); the incidence of hiccup, bradycardia, tachycardia, intraoperative hypotension, and respiratory depression of two groups were compared. Results At T2-T3, HR, MAP, and SO2 in control group were lower than those at T0, and the differences were statistically significant (P＜0.05); at T1-T4, HR, MAP, and SO2 in observation group were higher than those in control group, and the differences were statistically significant (P＜0.05). The induced dosage of Propofol in observation group was lower than that in control group, and the recovery time was shorter than that in control group, and the differences were statistically significant (P＜0.05). The incidence of hiccup, bradycardia, tachycardia, intraoperative hypotension, and respiratory depression in observation group was lower than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Dexmedetomidine in painless gastroenteroscopy patients can reduce the amount of Propofol induction, shorten the recovery time, reduce the impact on hemodynamics, and reduce the incidence of adverse reactions.
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