Study the medication rules of traditional Chinese medicine compound in the treatment of immune thrombocytopenia based on national patent database
LI Yang ZHU Wenwei LI Xiaojing REN Zirui
Department of Hematopathology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
Abstract：Objective To analyze the medication and prescription rules of the traditional Chinese medicine compound patent in the treatment of immune thrombocytopenia (ITP) based on the national patent database. Methods The Chinese medicine compound patents for treating ITP published in the National Patent Database were searched, and the search period was from the establishment of the database to May 1, 2022. The traditional Chinese medicine inheritance auxiliary platform V2.5 was used, and the frequency analysis, attribute analysis, association rules, and improved mutual information method as well as the complex system entropy clustering algorithm were performed in order to analyze and visualize the four natures and five flavors, meridian-returning efficacy, and prescriptions, and medication rules. Results A total of 78 traditional Chinese medicine compound patent were included. There were 218 kinds of Chinese herbs, and the top four with high frequency were milkvetch root, unprocessed rehmannia root, tree peony root bark, hairyvein agrimonia herb. The nature of drugs were mainly cold, and others were warm and calm; the five flavors were mainly sweet and bitter, followed by pungent; the liver, kidney and spleen meridians were in majority; there were 12 core combinations and six new prescriptions. Conclusion Traditional Chinese medicine compound are commonly used in the treatment of ITP by invigorating the qi, strengthening the spleen, nourishing the kidney, filling the essence, cooling the blood, promoting the blood circulation, and stopping the bleeding. At the same time, different core drug combinations are selected according to the pathogenesis, deficiency and physical characteristics to improve clinical efficacy.
李洋 朱文伟 李晓靖 任梓瑞. 基于国家专利数据库探讨中药复方治疗免疫性血小板减少症用药规律[J]. 中国医药导报, 2023, 20(6): 123-127.
LI Yang ZHU Wenwei LI Xiaojing REN Zirui. Study the medication rules of traditional Chinese medicine compound in the treatment of immune thrombocytopenia based on national patent database. 中国医药导报, 2023, 20(6): 123-127.
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